Coronavirus disease 2019 (COVID‐19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with considerable mortality worldwide. The main clinical manifestation of COVID‐19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. In this study, we review some of the potential effects of curcumin such as inhibiting the entry of virus to the cell, inhibiting encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS‐CoV‐2.

中文翻译：

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姜黄素在治疗 COVID-19 感染中的潜在作用


2019 年冠状病毒病 (COVID-19) 爆发是由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的持续大流行，在全球范围内造成相当大的死亡率。 COVID-19的主要临床表现是出现呼吸道症状，但部分患者出现严重的心血管和肾脏并发症。迫切需要了解这种病毒引起并发症的机制，以便制定治疗方案。姜黄素是一种天然多酚化合物，可能是冠状病毒病患者的潜在治疗选择。在这项研究中，我们回顾了姜黄素的一些潜在作用，例如抑制病毒进入细胞、抑制病毒和病毒蛋白酶的封装以及调节各种细胞信号通路。该综述为进一步研究和开发姜黄素治疗新出现的 SARS-CoV-2 的临床应用奠定了基础。