In this study, we developed contactless electrospray ionization mass spectrometry (ESI‐MS) for in vivo analysis of living organisms in different applications. The in vivo sampling and direct analysis processess of living organisms were integrated into an operation that only requires the organism close to MS inlet that was applied to a high voltage. Living plants and animals were directly induced to generate spray ionization. Direct detection and in vivo monitoring of metabolites and chemical residues in various living organisms were successfully demonstrated. Analysis of a single sample could be completed within 30 s. Overall, contactless ESI‐MS provides an attractive in vivo method to straightforward investigation of living organisms.

中文翻译：

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用于直接检测活生物体中分析物的非接触式电喷雾电离质谱法


在这项研究中，我们开发了非接触式电喷雾电离质谱（ESI-MS），用于不同应用中活体生物体的体内分析。将活体生物体的体内采样和直接分析过程集成到一个操作中，只需将生物体靠近施加高电压的 MS 入口即可。直接诱导活体植物和动物产生喷雾电离。成功地证明了对各种生物体中代谢物和化学残留物的直接检测和体内监测。单个样品的分析可在 30 秒内完成。总体而言，非接触式 ESI-MS 为直接研究活生物体提供了一种有吸引力的体内方法。