The neural mechanisms of drug cue‐reactivity regarding the temporal fluctuations of functional connectivity, namely the dynamic connectivity, are sparsely studied. Quantifying the task‐modulated variability in dynamic functional connectivity at cue exposure can aid the understanding. We analyzed changes in dynamic connectivity in 54 adult cannabis users and 90 controls during a cannabis cue exposure task. The variability was measured as standard deviation in the (a) connectivity weights of the default mode, the central executive, and the salience networks and two reward loci (amygdalae and nuclei accumbens); and (b) topological indexes of the whole brain (global efficiency, modularity and network resilience). These were compared for the main effects of task conditions and the group (users vs. controls), and correlated with pre‐ and during‐scan subjective craving. The variability of connectivity weights between the central executive network and nuclei accumbens was increased in users throughout the cue exposure task, and, was positively correlated with during‐scan craving for cannabis. The variability of modularity was not different by groups, but positively correlated with prescan craving. The variability of dynamic connectivity during cannabis cue exposure task between the central executive network and the nuclei accumbens, and, the level of modularity, seem to relate to the neural underpinning of cannabis use and the subjective craving.

中文翻译：

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伏隔核和中央执行网络之间的动态功能连接与长期使用大麻有关。

关于功能连接的时间波动的药物线索反应的神经机制，即动态连接，很少被研究。量化提示暴露时动态功能连接中任务调制的可变性可以帮助理解。我们分析了 54 名成年大麻使用者和 90 名对照者在大麻线索暴露任务期间动态连接的变化。可变性被测量为（a）默认模式、中央执行器、显着网络和两个奖励位点（杏仁核和伏隔核）的连接权重的标准偏差；(b) 全脑的拓扑指标（全局效率、模块性和网络弹性）。比较了任务条件和组（用户与对照组）的主要影响，并与扫描前和扫描期间的主观渴望相关。在整个提示暴露任务中，用户的中央执行网络和伏隔核之间连接权重的可变性增加，并且与扫描期间对大麻的渴望呈正相关。模块性的可变性在各组之间没有差异，但与扫描前渴望呈正相关。在中央执行网络和伏隔核之间的大麻线索暴露任务期间动态连接的可变性，以及模块化水平，似乎与大麻使用的神经基础和主观渴望有关。与扫描期间对大麻的渴望呈正相关。模块性的可变性在各组之间没有差异，但与扫描前渴望呈正相关。在中央执行网络和伏隔核之间的大麻线索暴露任务期间动态连接的可变性，以及模块化水平，似乎与大麻使用的神经基础和主观渴望有关。与扫描期间对大麻的渴望呈正相关。模块性的可变性在各组之间没有差异，但与扫描前渴望呈正相关。在中央执行网络和伏隔核之间的大麻线索暴露任务期间动态连接的可变性，以及模块化水平，似乎与大麻使用的神经基础和主观渴望有关。