Although it has been established that persistent infection with high risk human papillomavirus (HR-HPV) is the main cause in the development of cervical cancer, the HR-HPV infection is also related with the cause of a significant fraction of other human malignancies from the mucosal squamous epithelial such as anus, vagina, vulva, penis and oropharynx. HR-HPV infection induces cell proliferation, cell death evasion and genomic instability resulting in cell transformation, due to HPV proteins, which target and modify the function of differents cell molecules and organelles, such as mitochondria. Mitochondria are essential in the production of the cellular energy by oxidative phosphorylation (OXPHOS), in the metabolism of nucleotides, aminoacids (aa), and fatty acids, even in the regulation of cell death processes such as apoptosis or mitophagy. Thus, mitochondria have a significant role in the HPV-related cancer development. This review focuses on the role of HPV and mitochondria in HPV-related cancer development, and treatments associated to mitochondrial apoptosis.

中文翻译：

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人乳头瘤病毒相关的癌症和线粒体。

尽管已经确定持续感染高危型人乳头瘤病毒（HR-HPV）是宫颈癌发展的主要原因，但HR-HPV感染还与宫颈癌中其他大部分人类恶性肿瘤的病因有关。粘膜鳞状上皮，例如肛门，阴道，外阴，阴茎和口咽。HR-HPV感染可诱导细胞增殖，逃避细胞死亡和基因组不稳定，这归因于HPV蛋白，该蛋白靶向并修饰不同细胞分子和细胞器（例如线粒体）的功能。线粒体在通过氧化磷酸化（OXPHOS）产生细胞能量，在核苷酸，氨基酸（aa）和脂肪酸的代谢中，甚至在调节细胞死亡过程（例如凋亡或线粒体）中至关重要。因此，线粒体在HPV相关的癌症发展中具有重要作用。这篇综述集中在HPV和线粒体在HPV相关的癌症发展中的作用，以及与线粒体凋亡相关的治疗。