The loss of peroxisomal function has been implicated in many neurodegenerative diseases, yet the underlying molecular mechanisms are poorly understood. In this issue of Neuron, Chung et al. (2020) demonstrate that gain- and loss-of-function mutations in the peroxisomal acyl-CoA oxidase 1 (ACOX1) gene cause neurodegeneration via distinct molecular pathways in glia.

中文翻译：

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脂质代谢和轴突变性：ACOX1平衡法。

过氧化物酶体功能的丧失已牵涉到许多神经退行性疾病中，但对潜在的分子机制了解甚少。在本期《神经元》中，Chung等人。（2020）证明过氧化物酶体酰基辅酶A氧化酶1（ACOX1）基因中的功能获得和丧失功能突变通过神经胶质细胞中不同的分子途径引起神经变性。