Objective

To explore the relationships between serum copper levels and overweight/total obesity and central obesity in children and adolescents.

Methods

We included 2,000 children and adolescents from the 2011-2016 US National Health and Nutrition Examination Surveys. The multivariable linear model, logistic model and restricted cubic splines were adopted to assess the relationships. Models were adjusted for data release cycle, age, sex, race/ethnicity, ratio of family income to poverty, and dietary intakes of protein, total sugars, total fat, fiber, energy, calcium, vitamin D, vitamin C, and hours watch television or videos.

Results

The prevalences of overweight/total obesity and central obesity were 37.38% and 33.40%, respectively. For per-quintile increment in serum copper levels, body mass index increased by 1.06 (0.79-1.33) (kg/m²) and waist circumference increased by 2.43 (1.58-3.27) (cm). The odds ratios (95% confidence intervals) for overweight/total obesity and central obesity among participants with the highest quintile compared with those with the lowest quintile of serum copper levels were 5.46 (3.31-8.98) and 5.64 (3.31-9.58), respectively. The above-mentioned associations were not modified by age (children: 6-12 years, adolescents: 13-18 years) and sex. Dose-response analysis showed that the odds of overweight/total obesity and central obesity increased with increasing serum copper levels to a level of approximate 140 ug/dL where the association seemed to reach a plateau, respectively.

Conclusions

Serum copper levels were positively associated with body mass index and waist circumference, and elevated serum copper levels were associated with higher odds of overweight/total obesity and central obesity in children and adolescents.

中文翻译：

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6~18岁儿童青少年血清铜水平与超重/总体肥胖、向心性肥胖的关系

 客观的

探讨儿童青少年血清铜水平与超重/总体肥胖和向心性肥胖的关系。

 方法

我们纳入了 2011-2016 年美国国家健康和营养检查调查中的 2,000 名儿童和青少年。采用多变量线性模型、逻辑模型和限制三次样条来评估这种关系。模型根据数据发布周期、年龄、性别、种族/民族、家庭收入与贫困的比率以及蛋白质、总糖、总脂肪、纤维、能量、钙、维生素 D、维生素 C 的膳食摄入量和工作时间进行了调整电视或视频。

 结果

超重/总体肥胖和向心性肥胖患病率分别为37.38%和33.40%。血清铜水平每增加五分之一，体重指数增加1.06 (0.79-1.33) (kg/m ² )，腰围增加2.43 (1.58-3.27) (cm)。血清铜水平最高五分位的参与者与血清铜水平最低五分位的参与者相比，超重/总体肥胖和向心性肥胖的比值比（95%置信区间）分别为 5.46 (3.31-8.98) 和 5.64 (3.31-9.58)。 。上述关联不因年龄（儿童：6-12 岁，青少年：13-18 岁）和性别而改变。剂量反应分析表明，随着血清铜水平升高至大约 140 ug/dL，超重/总体肥胖和向心性肥胖的几率分别增加，此时相关性似乎达到平台期。

 结论

血清铜水平与体重指数和腰围呈正相关，血清铜水平升高与儿童和青少年超重/总体肥胖和中心性肥胖的几率较高相关。