Recent narrative reviews have described the potential efficacy of providing individuals infected with coronavirus disease 2019 (COVID-19) with additional micronutrients to reduce disease severity. Although there are compelling reasons why providing additional micronutrients or conditional amino acids may affect COVID-19-related outcomes, evidence is lacking. The objective of this scoping review is to explore and describe the literature examining the effect of providing additional micronutrients or conditional amino acids (glutamine, arginine) in adults with conditions or infections similar to COVID-19 infection on COVID-19-related health outcomes. A literature search of the MEDLINE database and hand search of Cochrane Database of systematic reviews retrieved 1,423 unique studies, and 8 studies were included in this scoping review. Four studies examined a target population with ventilator-related pneumonia and acute respiratory distress syndrome, and the other 4 studies included patients who were at risk for ventilator-associated pneumonia. Interventions included intravenous ascorbic acid, intramuscular cholecalciferol, enteral and intramuscular vitamin E, enteral zinc sulfate, and oral and parenteral glutamine. In 6 of the 8 included studies, baseline status of the nutrient of interest was not reported and, thus, it is uncertain how outcomes may vary in the context of nutrient deficiency or insufficiency compared with sufficiency. In the absence of direct evidence examining efficacy of providing additional micronutrients or conditional amino acids to standard care, registered dietitian nutritionists must rely on clinical expertise and indirect evidence to guide medical nutrition therapy for patients infected with COVID-19.

最近的叙述性评论描述了为感染 2019 冠状病毒病 (COVID-19) 的个体提供额外微量营养素以降低疾病严重程度的潜在功效。尽管提供额外微量营养素或条件性氨基酸可能会影响 COVID-19 相关结果的原因令人信服，但缺乏证据。本范围审查的目的是探索和描述文献，这些文献检查了在患有类似于 COVID-19 感染的病症或感染的成人中提供额外微量营养素或条件性氨基酸（谷氨酰胺、精氨酸）对 COVID-19 相关健康结果的影响。对 MEDLINE 数据库的文献检索和对 Cochrane 系统评价数据库的手动检索检索到了 1,423 项独特的研究，其中 8 项研究被纳入本范围综述。四项研究检查了呼吸机相关性肺炎和急性呼吸窘迫综合征的目标人群，其他 4 项研究纳入了有呼吸机相关性肺炎风险的患者。干预措施包括静脉注射抗坏血酸、肌内胆钙化醇、肠内和肌内维生素 E、肠内硫酸锌以及口服和胃肠外谷氨酰胺。在纳入的 8 项研究中，有 6 项未报告目标营养素的基线状态，因此，与充足相比，在营养素缺乏或不足的情况下，结果可能如何变化尚不确定。在没有直接证据检验向标准护理提供额外微量营养素或条件性氨基酸的功效的情况下，