Recent narrative reviews have described the potential efficacy of providing individuals infected with coronavirus disease 2019 (COVID-19) with additional micronutrients to reduce disease severity. Although there are compelling reasons why providing additional micronutrients or conditional amino acids may affect COVID-19-related outcomes, evidence is lacking. The objective of this scoping review is to explore and describe the literature examining the effect of providing additional micronutrients or conditional amino acids (glutamine, arginine) in adults with conditions or infections similar to COVID-19 infection on COVID-19-related health outcomes. A literature search of the MEDLINE database and hand search of Cochrane Database of systematic reviews retrieved 1,423 unique studies, and 8 studies were included in this scoping review. Four studies examined a target population with ventilator-related pneumonia and acute respiratory distress syndrome, and the other 4 studies included patients who were at risk for ventilator-associated pneumonia. Interventions included intravenous ascorbic acid, intramuscular cholecalciferol, enteral and intramuscular vitamin E, enteral zinc sulfate, and oral and parenteral glutamine. In 6 of the 8 included studies, baseline status of the nutrient of interest was not reported and, thus, it is uncertain how outcomes may vary in the context of nutrient deficiency or insufficiency compared with sufficiency. In the absence of direct evidence examining efficacy of providing additional micronutrients or conditional amino acids to standard care, registered dietitian nutritionists must rely on clinical expertise and indirect evidence to guide medical nutrition therapy for patients infected with COVID-19.

最近的叙述性评论描述了为感染 2019 年冠状病毒病 (COVID-19) 的个体提供额外的微量营养素以减轻疾病严重程度的潜在功效。尽管有令人信服的理由说明为什么提供额外的微量营养素或条件氨基酸可能会影响与 COVID-19 相关的结果，但缺乏证据。本次范围审查的目的是探索和描述文献，这些文献研究了为患有类似于 COVID-19 感染的病症或感染的成年人提供额外的微量营养素或条件氨基酸（谷氨酰胺、精氨酸）对 COVID-19 相关健康结果的影响。 MEDLINE 数据库的文献检索和 Cochrane 系统评价数据库的手工检索检索到 1,423 项独特的研究，其中 8 项研究纳入本次范围界定综述。四项研究检查了患有呼吸机相关性肺炎和急性呼吸窘迫综合征的目标人群，另外四项研究则纳入了有呼吸机相关性肺炎风险的患者。干预措施包括静脉注射抗坏血酸、肌内注射胆钙化醇、肠内和肌内维生素E、肠内硫酸锌以及口服和肠外谷氨酰胺。在 8 项纳入的研究中，有 6 项没有报告相关营养素的基线状态，因此，与营养素充足相比，不确定在营养素缺乏或不足的情况下结果如何变化。在缺乏直接证据来检验在标准护理中提供额外微量营养素或条件氨基酸的功效的情况下，注册营养师必须依靠临床专业知识和间接证据来指导感染 COVID-19 患者的医学营养治疗。