Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal a multi-step developmental process that defines how T cells transition from proliferating progenitors into terminally differentiated exhausted T cells.

中文翻译：

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绘制T细胞衰竭路线图。

暴露于慢性感染或恶性肿瘤会触发功能受损的所谓的精疲力竭的T细胞分化。在本期《免疫》中，贝尔特拉（Beltra）等人。揭示了一个多步骤的发育过程，该过程定义了T细胞如何从增殖祖细胞过渡到最终分化的疲惫T细胞。