Memory B cells (MBCs) expressing the transcription factor T-bet have been described in normal and dysregulated immune responses. In this issue of Immunity, Johnson et al. report that T-bet+ MBCs, formed in response to a primary influenza infection, contribute to protective antibody titers and persist mainly in the spleen with restricted trafficking between tissues.

中文翻译：

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T-bet +记忆B细胞保持原位。

表达转录因子T-bet的记忆B细胞（MBC）在正常和失调的免疫反应中已有描述。在本期《免疫》中，约翰逊等人。报告指出，针对原发性流感感染而形成的T-bet + MBC有助于保护性抗体的滴度，并且主要存在于脾脏中，组织间的转运受限。