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Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells.
Immunity ( IF 25.5 ) Pub Date : 2020-05-19 , DOI: 10.1016/j.immuni.2020.04.009
Abbie S Ireland 1 , Trudy G Oliver 1
Affiliation  

Neutrophil extracellular traps (NETs) can promote tumor growth and metastases, but whether NETs impact the tumor immune microenvironment remains underexplored. In this issue of Immunity, Teijeira et al. discover that NETs shield tumor cells from cytotoxic immune cells, resulting in impaired tumor clearance.

中文翻译:

中性粒细胞在肿瘤和细胞毒性免疫细胞之间建立了不可渗透的屏障。

中性粒细胞外陷阱(NETs)可以促进肿瘤的生长和转移,但是NETs是否影响肿瘤的免疫微环境仍未得到充分的研究。在本期《免疫》中,Teijeira等人。发现NETs可以保护肿瘤细胞免受细胞毒性免疫细胞的侵害,从而导致肿瘤清除率受损。
更新日期:2020-05-19
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