The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein, expressed on both healthy and cancer cells, plays a pivotal role in this balance by delivering a "don't eat me signal" upon binding to the Signal-regulatory protein alpha (SIRPα) receptor on myeloid cells. Here, we review the current understanding of the role of the CD47-SIRPα axis in physiological tissue homeostasis and as a promising therapeutic target in, among others, oncology, fibrotic diseases, atherosclerosis, and stem cell therapies. We discuss gaps in understanding and highlight where additional insight will be beneficial to allow optimal exploitation of this myeloid cell checkpoint as a target in human disease.

中文翻译：

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CD47-SIRPα免疫检查点。

骨髓细胞的细胞毒活性受通过抑制和激活受体传递的信号平衡的调节。在健康细胞和癌细胞上均表达的分化簇47（CD47）蛋白通过与信号调节蛋白α（SIRPα）受体结合后传递“不要吃我的信号”，在这种平衡中起着关键作用。骨髓细胞。在这里，我们回顾了目前对CD47-SIRPα轴在生理组织动态平衡中的作用的了解，并将其作为肿瘤，纤维化疾病，动脉粥样硬化和干细胞疗法等方面的有希望的治疗靶标。我们讨论了理解上的差距，并着重指出了哪些其他见识将有助于使该髓样细胞检查点作为人类疾病的靶标得到最佳利用。