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Centrosomal protein 55: A new paradigm in tumorigenesis.
European Journal of Cell Biology ( IF 4.5 ) Pub Date : 2020-05-20 , DOI: 10.1016/j.ejcb.2020.151086
Divya Tandon 1 , Monisha Banerjee 1
Affiliation  

Centrosomal Protein 55 (Cep55), also known as c10orf3 and FLJ10540, was initially discovered as a major player in abscission, the final stage of cytokinesis. Subsequent studies have described its role in regulating the PI3K/AKT pathway, increasing cancer cell stemness, and promoting tumor formation. Clinically, Cep55 has been found to be overexpressed in many cancer types. Cep55 overexpression has been notably associated with tumor stage, tumor aggressiveness, poor prognosis, and metastasis. The present review discusses the role of Cep55 as a crucial biomarker and model in tumorigenesis.



中文翻译:

中心体蛋白55:肿瘤发生的新范例。

中心蛋白55(Cep55),也称为c10orf3和FLJ10540,最初被发现是脱落的主要参与者,脱落是胞质分裂的最后阶段。随后的研究描述了其在调节PI3K / AKT途径,增加癌细胞干性和促进肿瘤形成中的作用。在临床上,已发现Cep55在许多癌症类型中过表达。Cep55过度表达与肿瘤分期,肿瘤侵袭性,预后不良和转移密切相关。本综述讨论了Cep55在肿瘤发生中的关键生物标志物和模型的作用。

更新日期:2020-05-20
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