Many groups have utilized argon plasma and the “Grafting-From” approach as a means for the modification of surfaces at the macro-scale. However, very few have utilized this technique for the modification of surfaces at the nano-scale, due to the idea that plasmas destroy the chemical integrity of materials at the nano-scale. In this study, argon plasma grafting technology was used as an initiator for the surface modification of carbon and titanium oxide nanoparticles. When constructed using optimized experimental conditions, grafted nanoparticles containing polyacrylic acid possessed significantly different chemical and physical properties in comparison to plasma treated and polyacrylic acid coated nanoparticles. It is reported that the grafted nanoparticles, when compared to coated nanoparticles, were extremely stable, resulting in negligible amounts of polymer degradation after exposure to a wide range of experimental conditions including solutions of different pH ranging from 3 to 11, simulated body fluid, 2% fetal bovine serum, and phosphate buffered saline solutions with temperatures ranging from 20 to 100 °C. The results discussed in this work provide evidence for the potential application of the plasma-assisted modification technique as a possible means to solve many of the concerns regarding drug and gene delivery systems.

许多小组已经使用氩等离子体和“从-嫁接”方法作为宏观修饰表面的方法。然而，由于等离子体破坏了纳米级材料的化学完整性的思想，因此很少有人将该技术用于纳米级表面的改性。在这项研究中，氩等离子体接枝技术被用作碳和二氧化钛纳米粒子表面改性的引发剂。当使用优化的实验条件构建时，与等离子体处理的和聚丙烯酸涂层的纳米粒子相比，含聚丙烯酸的接枝纳米粒子具有明显不同的化学和物理性质。据报道，与包覆纳米粒子相比，接枝纳米粒子非常稳定，暴露于各种实验条件（包括不同pH范围为3至11的溶液，模拟体液，2％胎牛血清和温度为20至100°P的磷酸盐缓冲盐溶液）导致的聚合物降解量可忽略不计C。这项工作中讨论的结果为血浆辅助修饰技术作为解决许多与药物和基因传递系统有关的问题的可能手段的潜在应用提供了证据。