OBJECTIVE This study was performed to compare the effects of a vapocoolant spray and an eutectic mixture of local anesthetics (EMLA) cream on reducing pain during intraarticular (IA) injection of the shoulder. DESIGN Double-blind randomized placebo-controlled clinical trial. SETTING University hospital. PARTICIPANTS Sixty-three patients who underwent IA injection of the shoulder joint were randomized into the spray group, EMLA group, or placebo group. INTERVENTION Placebo cream + vapocoolant spray (spray group), EMLA cream + placebo spray (EMLA group), or placebo cream + placebo spray (placebo group) before IA injection. MAIN OUTCOME MEASURES A 100-mm visual analog scale (VAS) for injection pain and 5-point Likert scales for participant satisfaction and preference for repeated use were administered immediately after IA injection. RESULTS The VAS scores for pain during IA injection were 30.0 (95% confidence interval: 19.7-41.2) in the spray group, 50.0 (37.7-63.0) in the EMLA group, and 53.8 (41.6-65.0) in the placebo group (F = 6.403, P < 0.01). The spray group showed significantly better Likert scale scores than the placebo group for participant satisfaction (P = 0.003) and preference for repeated use (P < 0.001). CONCLUSIONS Vapocoolant spray was effective in reducing pain during IA injection of the shoulder.

中文翻译：

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Vapocoolant Spray 和局部麻醉霜对肩关节内注射疼痛影响的比较：一项随机双盲对照试验

目的 本研究旨在比较蒸汽冷却剂喷雾和局部麻醉剂 (EMLA) 霜的低共熔混合物对减轻肩关节内 (IA) 注射过程中疼痛的影响。设计 双盲随机安慰剂对照临床试验。设置大学医院。参与者 63 名接受肩关节 IA 注射的患者随机分为喷雾组、EMLA 组或安慰剂组。干预 IA 注射前使用安慰剂乳膏 + 蒸汽冷却喷雾（喷雾组）、EMLA 乳膏 + 安慰剂喷雾（EMLA 组）或安慰剂乳膏 + 安慰剂喷雾（安慰剂组）。主要观察指标 注射疼痛的 100 毫米视觉模拟量表 (VAS) 和参与者满意度和重复使用偏好的 5 点李克特量表在 IA 注射后立即进行。结果 IA 注射期间疼痛的 VAS 评分在喷雾组中为 30.0（95% 置信区间：19.7-41.2），在 EMLA 组中为 50.0（37.7-63.0），在安慰剂组中为 53.8（41.6-65.0）（F = 6.403，P < 0.01）。在参与者满意度（P = 0.003）和重复使用偏好（P < 0.001）方面，喷雾组的李克特量表得分显着优于安慰剂组。结论 Vapocoolant 喷雾可有效减轻肩部 IA 注射过程中的疼痛。003) 和重复使用的偏好 (P < 0.001)。结论 Vapocoolant 喷雾可有效减轻肩部 IA 注射过程中的疼痛。003) 和重复使用的偏好 (P < 0.001)。结论 Vapocoolant 喷雾可有效减轻肩部 IA 注射过程中的疼痛。