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The prevalence of restless legs syndrome in patients undergoing coronary angiography and its relationship with the severity of coronary artery stenosis
Sleep and Breathing ( IF 2.1 ) Pub Date : 2020-05-19 , DOI: 10.1007/s11325-020-02085-2
Dürdane Aksoy 1 , Ataç Çelik 2 , Volkan Solmaz 3 , Betül Çevik 1 , Orhan Sümbül 1 , Semiha Kurt 1
Affiliation  

Purpose Results from studies on the relationship between restless legs syndrome (RLS) and coronary artery disease (CAD) are conflicting. Some studies associate RLS with CAD by heart rate variability, blood pressure variability, and other autonomic, neuronal reasons, while other studies do not support these observations. The aim of this study was to investigate the prevalence of RLS in patients undergoing coronary angiography for CAD and to assess RLS prevalence with severity of CAD. Methods After inclusion and exclusion criteria were applied, enrolled patients with less than 50% coronary artery stenosis by angiography (0–49%) were assigned to group 1, and patients with 50% or more coronary artery stenosis were assigned to group 2. Patients were diagnosed with RLS if they met all five essential criteria of the International RLS study group. RLS prevalence and other comorbidities were compared between the two groups. Results Of 126 patients, 74 men (59%), mean age 64.0 ± 8.7 years, mean BMI 29.6 kg/m2, 47 (37%) were assigned to group 1 (no or nonobstructive CAD) and 79 (63%) were assigned to group 2 (obstructive CAD). No significant differences were found between the groups in terms of mean age, BMI, gender, or prevalence of hypertension, hypercholesterolemia, and DM. The prevalence of RLS in group 2 (29%) was significantly higher than in group 1 (15%), p = 0.013. Conclusion These results suggest that prevalence of RLS is associated with CAD and with CAD severity. We conjecture that RLS may be related to vascular endothelial dysfunction in cardiovascular disease.

中文翻译:

冠状动脉造影患者不宁腿综合征的患病率及其与冠状动脉狭窄严重程度的关系

目的 不安腿综合征 (RLS) 与冠状动脉疾病 (CAD) 之间关系的研究结果相互矛盾。一些研究通过心率变异性、血压变异性和其他自主神经元原因将 RLS 与 CAD 联系起来,而其他研究不支持这些观察结果。本研究的目的是调查接受冠状动脉造影术的 CAD 患者的 RLS 患病率,并评估 RLS 患病率与 CAD 的严重程度。方法 应用纳入和排除标准后,纳入的血管造影冠状动脉狭窄小于 50%(0-49%)的患者被分配到第 1 组,冠状动脉狭窄超过 50% 的患者被分配到第 2 组。如果他们符合国际 RLS 研究组的所有五个基本标准,则被诊断为 RLS。比较两组的 RLS 患病率和其他合并症。结果 在 126 名患者中,74 名男性 (59%),平均年龄 64.0 ± 8.7 岁,平均 BMI 29.6 kg/m2,47 名 (37%) 被分配到第 1 组(无或非阻塞性 CAD),79 名(63%)被分配到到第 2 组(阻塞性 CAD)。两组之间在平均年龄、BMI、性别或高血压、高胆固醇血症和 DM 的患病率方面没有显着差异。第 2 组 (29%) 的 RLS 患病率显着高于第 1 组 (15%),p = 0.013。结论 这些结果表明 RLS 的患病率与 CAD 和 CAD 严重程度相关。我们推测RLS可能与心血管疾病中的血管内皮功能障碍有关。0 ± 8.7 岁,平均 BMI 29.6 kg/m2,47 (37%) 名被分配到第 1 组(无或非阻塞性 CAD),79 (63%) 名被分配到第 2 组(阻塞性 CAD)。两组之间在平均年龄、BMI、性别或高血压、高胆固醇血症和 DM 的患病率方面没有显着差异。第 2 组 (29%) 的 RLS 患病率显着高于第 1 组 (15%),p = 0.013。结论 这些结果表明 RLS 的患病率与 CAD 和 CAD 严重程度相关。我们推测RLS可能与心血管疾病中的血管内皮功能障碍有关。0 ± 8.7 岁,平均 BMI 29.6 kg/m2,47 (37%) 名被分配到第 1 组(无或非阻塞性 CAD),79 (63%) 名被分配到第 2 组(阻塞性 CAD)。两组之间在平均年龄、BMI、性别或高血压、高胆固醇血症和 DM 的患病率方面没有显着差异。第 2 组 (29%) 的 RLS 患病率显着高于第 1 组 (15%),p = 0.013。结论 这些结果表明 RLS 的患病率与 CAD 和 CAD 严重程度相关。我们推测RLS可能与心血管疾病中的血管内皮功能障碍有关。或高血压、高胆固醇血症和 DM 的患病率。第 2 组 (29%) 的 RLS 患病率显着高于第 1 组 (15%),p = 0.013。结论 这些结果表明 RLS 的患病率与 CAD 和 CAD 严重程度相关。我们推测RLS可能与心血管疾病中的血管内皮功能障碍有关。或高血压、高胆固醇血症和 DM 的患病率。第 2 组 (29%) 的 RLS 患病率显着高于第 1 组 (15%),p = 0.013。结论 这些结果表明 RLS 的患病率与 CAD 和 CAD 严重程度相关。我们推测RLS可能与心血管疾病中的血管内皮功能障碍有关。
更新日期:2020-05-19
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