A few observational studies and randomized trials suggest that exercise and rehabilitation may improve activity limitation and quality of life (QoL) in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but the impact of other modifiable factors on the severity of the disease is not well understood. Using a structured questionnaire, we collected data on lifestyle and dietary habits of the patients included in the Italian CIDP database to investigate the possible influence of modifiable lifestyle factors on disability and QoL. Questionnaire data were available for 323 patients. The effect of lifestyle and dietary exposures on impairment, disability and QoL was evaluated using logistic regression models, adjusting for age, sex, disease duration, physical activity and smoking. Physical activity was associated with lower sensory impairment by the ISS scale, less disability by the INCAT and RODS scale and a better QoL in all the domains of EURO-QoL scale with the exception of anxiety/depression. None of the other parameters had an impact on these scales. This study adds evidence to the possible role of physical activity in improving symptom severity, disability and QoL in patients with CIDP. None of the other environmental factors investigated appeared to have an impact on the severity and health perception of CIDP.

中文翻译：

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环境因素和体育活动对CIDP残疾和生活质量的影响。

一些观察性研究和随机试验表明，运动和康复可能会改善慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）患者的活动受限和生活质量（QoL），但其他可改变因素对疾病严重程度的影响并不明显了解。使用结构化问卷，我们收集了意大利CIDP数据库中所包括的患者生活方式和饮食习惯数据，以调查可改变的生活方式因素对残疾和生活质量的可能影响。可获得323名患者的问卷调查数据。使用逻辑回归模型，评估了年龄，性别，疾病持续时间，身体活动和吸烟，评估了生活方式和饮食暴露对障碍，残疾和生活质量的影响。ISS量表的体育活动与较低的感觉障碍，INCAT和RODS量表的残疾较少，EURO-QoL量表的所有领域（焦虑/抑郁除外）的QoL较好有关。其他参数均不影响这些量表。这项研究为体育锻炼在改善CIDP患者症状严重性，残疾和QoL中的可能作用提供了证据。调查的其他环境因素均未对CIDP的严重程度和健康感知产生影响。这项研究为体育锻炼在改善CIDP患者症状严重性，残疾和QoL中的可能作用提供了证据。调查的其他环境因素均未对CIDP的严重程度和健康感知产生影响。这项研究为体育锻炼在改善CIDP患者症状严重性，残疾和QoL中的可能作用提供了证据。调查的其他环境因素均未对CIDP的严重程度和健康感知产生影响。