PURPOSE To compare fertility preservation (FP) outcomes among adolescent transgender males with those of cisgender females. METHODS This retrospective cohort study included nine adolescent transgender males and 39 adolescent cisgender females who underwent FP between January 2017-April 2019 and September 2013-April 2019, respectively. The transgender males were referred before initiating testosterone, and the cisgender females were referred due to cancer diagnosis before starting anticancer treatment. Statistical analyses compared assisted reproductive technology (ART) data and FP outcomes between two groups. RESULTS Basal FSH levels (5.4 ± 1.7 mIU/mL) and AFC (19.8 ± 5.6) of all transgender males were normal compared with standard references. The mean age of transgender males and cisgender females was similar (16.4 ± 1.1 vs 15.5 ± 1.3 years, respectively, P = 0.064). The amount of FSH used for stimulation was significantly lower among the former compared with the latter (2416 ± 1041 IU vs 4372 ± 1877 IU, P < 0.001), but the duration of stimulation was similar (12.6 ± 4.0 and 10.1 ± 2.8 days, P = 0.086). Peak estradiol level was significantly higher among transgender males compared with cisgender females (3073 ± 2637 pg/mL vs 1269 ± 975 pg/mL, respectively, P = 0.018), but there were no significant differences in number of retrieved oocytes between the two groups (30.6 ± 12.8 vs 22 ± 13.2, P = 0.091), number of MII oocytes (25.6 ± 12.9 vs 18.8 ± 11.2, P = 0.134), or maturity rates (81.5 ± 10.0% vs 85.4 ± 14.6%, P = 0.261). CONCLUSIONS Adolescent transgender males have an excellent response to ovulation stimulation before initiating testosterone treatment. Oocyte cryopreservation is, therefore, a feasible and effective way for them to preserve their fertility for future biological parenting.

中文翻译：

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青春期跨性别男性的卵母细胞取回结果。

目的比较青春期变性男性和顺性别女性的保留生育能力。方法这项回顾性队列研究包括2017年1月至2019年4月和2013年9月至2019年4月分别接受FP的9例青春期变性男性和39例青春期顺性别的女性。在开始睾丸激素治疗之前先检查了变性人，在开始抗癌治疗之前，由于癌症的诊断而检查了顺性别的女人。统计分析比较了两组之间的辅助生殖技术（ART）数据和FP结果。结果与标准对照相比，所有跨性别男性的基础FSH水平（5.4±1.7 mIU / mL）和AFC（19.8±5.6）均正常。跨性别男性和顺性别女性的平均年龄相近（分别为16.4±1.1岁和15.5±1.3岁，分别为P = 0.064）。前者用于刺激的FSH量显着低于后者（2416±1041 IU vs 4372±1877 IU，P <0.001），但刺激时间相似（12.6±4.0和10.1±2.8天， P = 0.086）。跨性别男性中的雌二醇峰值水平显着高于顺性别女性（分别为3073±2637 pg / mL和1269±975 pg / mL，P = 0.018），但两组之间回收的卵母细胞数量没有显着差异。 （30.6±12.8 vs 22±13.2，P = 0.091），MII卵母细胞数（25.6±12.9 vs 18.8±11.2，P = 0.134）或成熟率（81.5±10.0％vs 85.4±14.6％，P = 0.261） 。结论在开始睾丸激素治疗之前，青春期变性男性对排卵刺激有良好的反应。