A synthesis of (Z)-alkene-containing linear conjugated dienyl homoallylic alcohols by using a palladium-catalyzed three-component reaction has been developed. This method shows good functional-group compatibility and generality, with high diastereoselectivity. Additionally, in many cases, the present method controls the alkene stereochemistry of the newly formed C–C bond and overcomes the inherent preference for (E)-alkene formation, giving (Z,E)- and (Z,Z)-products.

中文翻译：

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钯催化三组分反应合成含 (Z)-烯烃的直链共轭二烯基高烯丙醇

已经开发了通过使用钯催化的三组分反应合成含 (Z)-烯烃的线性共轭二烯基高烯丙醇。该方法显示出良好的官能团兼容性和通用性，具有较高的非对映选择性。此外，在许多情况下，本方法控制了新形成的 C-C 键的烯烃立体化学，并克服了对 (E)-烯烃形成的固有偏好，得到了 (Z,E)- 和 (Z,Z)-产物。