BACKGROUND Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. METHODS Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearman's correlation analysis was used to examine the association of the serum Fetuin-A with other parameters. RESULTS Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 μg/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p <  0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 μg/L. CONCLUSION Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.

中文翻译：

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多囊卵巢综合征女性的血清Fetuin-A水平升高并与胰岛素抵抗相关。

背景技术胰岛素抵抗（IR）是多囊卵巢综合征（PCOS）妇女的共同特征。据报道，循环Fetuin-A水平与IR和2型糖尿病（T2DM）有关。但是，以前的报告不一致。方法根据鹿特丹共识标准的诊断指南对207例PCOS进行筛查。使用ELISA试剂盒测量血清胎球蛋白A水平。使用独立的t检验或非参数检验来检测PCOS和对照组之间的差异。使用Spearman相关分析分析血清Fetuin-A与其他参数的关联。结果我们的研究结果表明，大多数无PCOS的女性（95％）的循环Fetuin-A浓度范围为196.6至418.2μg/ L。患有PCOS的女性的循环Fetuin-A水平高于健康女性（437.9±119.3和313.8±60.5μg/ L； p <0.01）。血清胎球蛋白A与BMI，WHR，TG，TC，LDL-C，HOMA-IR，LH，T和DHEA-S正相关。多元回归分析表明，WHR，TG，HOMA-IR和DHEA-S是循环Fetuin-A水平的独立预测因子。二元逻辑回归分析显示血清胎球蛋白A与PCOS的发生有关。此外，我们的ROC曲线分析发现，Fetuin-A预测PCOS和IR的临界值为366.3和412.6μg/ L。结论血液胎球蛋白A可能是筛查女性PCOS和IR的有用生物标志物。和DHEA-S。多元回归分析表明，WHR，TG，HOMA-IR和DHEA-S是循环Fetuin-A水平的独立预测因子。二进制逻辑回归分析表明血清胎球蛋白-A与PCOS的发生有关。此外，我们的ROC曲线分析发现，Fetuin-A预测PCOS和IR的临界值为366.3和412.6μg/ L。结论血液胎球蛋白A可能是筛查女性PCOS和IR的有用生物标志物。和DHEA-S。多元回归分析表明，WHR，TG，HOMA-IR和DHEA-S是循环Fetuin-A水平的独立预测因子。二元逻辑回归分析表明血清Fetuin-A与PCOS的发生有关。此外，我们的ROC曲线分析发现，Fetuin-A预测PCOS和IR的临界值为366.3和412.6μg/ L。结论血液胎球蛋白A可能是筛查女性PCOS和IR的有用生物标志物。