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Hybrid Blood Collection Tubes: Combining the Best Attributes of Glass and Plastic for Safety and Shelf life.
SLAS Technology: Translating Life Sciences Innovation ( IF 2.5 ) Pub Date : 2020-05-19 , DOI: 10.1177/2472630320915842
Christopher M Weikart 1 , Adam P Breeland 1 , Matt S Wills 1 , Martin E Baltazar-Lopez 1
Affiliation  

SiO2 Medical Products, Inc. developed hybrid blood collection tubes (BCTs) that combine the breakage resistance of plastic and a shelf life approaching that of glass. These blended attributes provide improved BCT safety and reliability for patients and clinical workers. A shelf life of at least 2 y with less than 10% draw volume variation was demonstrated on evacuated hybrid BCTs, which is approximately 7 times longer than standard polyethylene terephthalate (PET) BCTs. This translates into more consistent and reliable blood draw volumes over a longer shelf life. The moisture vapor barrier of hybrid BCTs is 5 times lower than that of PET BCTs, which significantly reduces preservative evaporation over their shelf life. As a result, the risk of preservative gelation and alteration to the blood-to-preservative ratio mix is practically eliminated. Cyclic olefin polymer (COP) exhibits superior impact resistance to breakage because of its high ductility and impact strength and is not influenced by defects and flaws as is glass. Although COP has a mechanical toughness comparable with that of PET, it maintains this over a wider range of temperatures (-70 to 121 °C). As a result, COP can tolerate steam sterilization and cold storage temperatures without mechanical fatigue, deformation, or breakage. Lastly, extreme centrifugation of water-filled BCTs did not impose breakage of any kind.

中文翻译:

混合采血管:结合玻璃和塑料的最佳特性,以确保安全和保质期。

SiO2 Medical Products, Inc. 开发了混合采血管 (BCT),它结合了塑料的抗破损性和接近玻璃的保质期。这些混合属性为患者和临床工作者提供了更高的 BCT 安全性和可靠性。真空混合 BCT 的保质期至少为 2 年,拉伸体积变化小于 10%,比标准聚对苯二甲酸乙二醇酯 (PET) BCT 长约 7 倍。这意味着在更长的保质期内更一致和更可靠的抽血量。混合 BCT 的湿气阻隔性比 PET BCT 低 5 倍,这显着降低了其保质期内的防腐剂蒸发。结果,防腐剂凝胶化和改变血液与防腐剂比例混合物的风险实际上被消除了。环烯烃聚合物 (COP) 由于其高延展性和冲击强度而表现出优异的抗断裂性,并且不像玻璃那样受缺陷和瑕疵的影响。尽管 COP 具有与 PET 相当的机械韧性,但它可以在更宽的温度范围内(-70 至 121 °C)保持这种韧性。因此,COP 可以耐受蒸汽灭菌和冷藏温度,而不会出现机械疲劳、变形或破损。最后,充满水的 BCT 的极端离心不会造成任何类型的破损。因此,COP 可以耐受蒸汽灭菌和冷藏温度,而不会出现机械疲劳、变形或破损。最后,充满水的 BCT 的极端离心不会造成任何类型的破损。因此,COP 可以耐受蒸汽灭菌和冷藏温度,而不会出现机械疲劳、变形或破损。最后,充满水的 BCT 的极端离心不会造成任何类型的破损。
更新日期:2020-05-19
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