Abstract Social epigenomics is a new field of research that studies how the social environment shapes the epigenome and how in turn the epigenome modulates behavior. We focus on describing known gene–environment interactions (GEIs) and epigenetic mechanisms in different mammalian social systems. To illustrate how epigenetic mechanisms integrate GEIs, we highlight examples where epigenetic mechanisms are associated with social behaviors and with their maintenance through neuroendocrine, locomotor, and metabolic responses. We discuss future research trajectories and open questions for the emerging field of social epigenomics in nonmodel and naturally occurring social systems. Finally, we outline the technological advances that aid the study of epigenetic mechanisms in the establishment of GEIs and vice versa.

中文翻译：

---

哺乳动物社会系统的表观基因组学和基因调控


摘要 社会表观基因组学是一个新的研究领域，研究社会环境如何塑造表观基因组以及表观基因组如何调节行为。我们专注于描述不同哺乳动物社会系统中已知的基因-环境相互作用（GEIs）和表观遗传机制。为了说明表观遗传机制如何整合 GEIs，我们重点介绍表观遗传机制与社会行为及其通过神经内分泌、运动和代谢反应维持相关的例子。我们讨论非模型和自然发生的社会系统中社会表观基因组学新兴领域的未来研究轨迹和开放问题。最后，我们概述了有助于研究建立 GEIs 的表观遗传机制的技术进步，反之亦然。