Phylogenetic analysis of the Y-chromosome haplogroup C2b-F1067, a dominant paternal lineage in Eastern Eurasia.,Journal of Human Genetics

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Phylogenetic analysis of the Y-chromosome haplogroup C2b-F1067, a dominant paternal lineage in Eastern Eurasia.
Journal of Human Genetics ( IF 2.6 ) Pub Date : 2020-05-19 , DOI: 10.1038/s10038-020-0775-1
Qiao Wu ₁ , Hui-Zhen Cheng ₂ , Na Sun ₃ , Peng-Cheng Ma ₄ , Jin Sun ₂ , Hong-Bing Yao ₅ , Yong-Mei Xie ₆ , Yong-Lan Li ₆ , Song-Lin Meng ₇ , Maxat Zhabagin _{8,

9} , Yan-Huan Cai ₂ , Da-Ru Lu ₁ , Shi Yan ₁₀ , Lan-Hai Wei _{2,

9}

Affiliation

State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, 2005 Songhu Road, 200438, Shanghai, China.
Department of Anthropology and Ethnology, Institute of Anthropology, Xiamen University, 361005, Xiamen, China.
College of Foreign Languages, Huaqiao University, 362021, Quanzhou, China.
School of Life Sciences, Jilin University, 130012, Changchun, China.
Key Laboratory of Evidence Science of Gansu Province, Gansu University of Political Science and Law, Lanzhou, China.
Laboratory for Human Biology and Human Genetics, Institute of Ethnology and Anthropology, School of Ethnology and Anthropology, Inner Mongolia Normal University, 010022, Hohhot, China.
School of History and Ethnic Culture, Hulunbuir University, 021008, Hulunbuir, China.
National Center for Biotechnology, Astana, 010000, Kazakhstan.
B&R International Joint Laboratory for Eurasian Anthropology, Fudan University, 20043, Shanghai, China.
Human Phenome Institute, Fudan University, Shanghai, China.

Human Y-chromosome haplogroup C2b-F1067 is one of the dominant paternal lineages of populations in Eastern Eurasia. In order to explore the origin, diversification, and expansion of this haplogroup, we generated 206 new Y-chromosome sequences from C2b-F1067 males and coanalyzed 220 Y-chromosome sequences of this haplogroup. BEAST software was used to reconstruct a revised phylogenetic tree of haplogroup C2b-F1067 with age estimates. The revised phylogeny of C2b-F1067 included 155 sublineages, 1986 non-private variants, and >6000 private variants. The age estimation suggested that the initial splitting of C2b-F1067 happened at about 32.8 thousand years ago (kya) and the major sublineages of this haplgroup experienced continuous expansion in the most recent 10,000 years. We identified numerous sublineages that were nearly specific for Korean, Mongolian, Chinese, and other ethnic minorities in China. In particular, we evaluated the candidate-specific lineage for the Dayan Khan family and the Confucius family, the descendants of the ruling family of the Chinese Shang dynasty. These findings suggest that ancient populations with varied C2b-F1067 sublineages played an important role during the formation of most modern populations in Eastern Eurasia, and thus eventually became the founding paternal lineages of these populations.

更新日期：2020-05-19

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