This study aimed to evaluate the predictive value of procalcitonin (PCT) in ventilator-associated pneumonia (VAP) after cardiac valve replacement. A total of 80 patients who underwent cardiac valve replacement in our department were enrolled in this study. Of these patients,40 were diagnosed with VAP and assigned to the observation group, while the other 40 patients not diagnosed with VAP were assigned to the control group. The changes in serum PCT, white blood cell count and C-reactive protein (CRP) were observed before each operation (T0), on the first day after the operation (T1), the second day after the operation (T2) and the third day after the operation (T3). After the operation, the serum PCT in the observation group was significantly higher than those at different time points after the operation, and also significantly higher than those in the control group (p < .05). In the control group, PCT was significantly higher after the operation than before the operation (p < .05), but the differences among the different postoperative time points were not statistically significant (p > .05). In the two groups, the white blood cell count and CRP were significantly higher after the operation than before the operation (p < .05), but the differences between the two groups were not statistically significant (p > .05). Serum PCT is an early, sensitive and highly specific high-risk monitoring index and has an early prediction value for VAP after cardiac valve replacement.

这项研究的目的是评估心脏瓣膜置换术后降钙素原（PCT）在呼吸机相关性肺炎（VAP）中的预测价值。本研究共纳入80例行心脏瓣膜置换术的患者。在这些患者中，有40例被诊断为VAP并被分配到观察组，而其他40例未被诊断为VAP的患者被分配为对照组。在每次手术前（T0），手术后第一天（T1），手术后第二天（T2）和第三天观察血清PCT，白细胞计数和C反应蛋白（CRP）的变化手术后一天（T3）。手术后，观察组血清PCT明显高于手术后不同时间点。p  <.05）。对照组中，术后PCT显着高于手术前（p  <.05），但术后不同时间点之间的差异无统计学意义（p  > .05）。两组术后白细胞计数和CRP均显着高于手术前（p  <0.05），但两组间差异无统计学意义（p  > 0.05）。血清PCT是一种早期，敏感且高度特异性的高风险监测指标，对心脏瓣膜置换术后的VAP具有早期预测价值。