Abstract

Objective

Cortical dynamics is driven by cortico-cortical connectivity and it characterizes cortical morphological features. These brain surface features complement volumetric changes and may offer improved understanding of disease pathophysiology. Hence, present study aims to investigate surface features; cortical thickness (CT) and gyrification index (GI) in Parkinson’s disease (PD) patients of normal cognition (PD-CN), cognitively impaired patients with PD (PD-CI) in comparison with cognitively normal healthy controls (HC) to better elucidate cognition linked features in PD.

Method

Anatomical MRI (3DT1) was carried out in 30 HC (56.53 ± 8.42 years), 30 PD-CN (58.8 ± 6.07 years), and 30 PD-CI (60.3 ± 6.43 years) subjects. Whole brain ROI based parcellation using Desikan-Killiany (DK-40) atlas followed by regional CT and GI differentiation [with ‘age’ and ‘total intracranial volume’ (TIV) correction], multiple linear regression (with ‘age’, ‘TIV’, and ‘education’ correction) with clinical variables, ROC analysis, and CT-GI correlation across the groups was used for data analysis.

Results

Widespread cortical thinning with regional GI reduction was evident in PD-CI with respect to other two groups (HC and PD-CN), and with absence of such alterations in PD-CN compared to HC. Frontal, parietal, and temporal CT/GI significantly correlated with cognition and presented classification abilities for cognitive state in PD. Mean regional CT and GI were found negatively correlated across groups with heterogeneous regions.

Conclusion

Fronto-parietal and temporal regions suffer cognition associated cortical thinning and GI reduction. CT may serve better discriminator properties and may be more consistent than GI in studying cognition in PD. Heterogeneous surface dynamics across the groups may signify neuro-developmental alterations in PD.

中文翻译：

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皮质厚度和回旋指数测量帕金森病的认知

摘要

客观的

皮层动力学由皮层-皮层连接驱动，它表征皮层形态特征。这些脑表面特征补充了体积变化，并可能提供对疾病病理生理学的更好理解。因此，本研究旨在研究表面特征；与认知正常的健康对照组 (HC) 相比，认知正常的帕金森病 (PD) 患者 (PD-CN)、认知受损的 PD (PD-CI) 患者的皮质厚度 (CT) 和回旋指数 (GI) 以更好地阐明PD中的认知相关特征。

方法

在 30 名 HC（56.53 ± 8.42 岁）、30 名 PD-CN（58.8 ± 6.07 岁）和 30 名 PD-CI（60.3 ± 6.43 岁）受试者中进行了解剖 MRI (3DT1)。使用 Desikan-Killiany (DK-40) 图谱进行基于全脑 ROI 的分割，然后进行区域 CT 和 GI 分化 [使用“年龄”和“颅内总体积”(TIV) 校正]，多元线性回归 (使用“年龄”、“TIV” '，和'教育'校正）与临床变量、ROC 分析和跨组的 CT-GI 相关性用于数据分析。

结果

与其他两组（HC 和 PD-CN）相比，PD-CI 中广泛的皮质变薄和区域 GI 减少是明显的，并且与 HC 相比，PD-CN 没有这种变化。额叶、顶叶和颞叶 CT/GI 与认知显着相关，并呈现 PD 认知状态的分类能力。发现平均区域 CT 和 GI 在具有异质区域的组之间呈负相关。

结论

额顶叶和颞叶区域遭受认知相关的皮质变薄和 GI 减少。CT 可以提供更好的鉴别特性，并且在研究 PD 的认知方面可能比 GI 更一致。各组的异质表面动力学可能表明 PD 的神经发育改变。