Bone marrow stromal antigen 2 (BST2) is a transmembrane glycoprotein and plays an essential role in innate immunity. Here we firstly found that BST2 expression was significantly elevated in hepatocellular carcinoma (HCC) tissues. High BST2 was closely related to the larger tumor size and more tumor number. Moreover, HCC patients with higher expression of BST2 had poorer overall survival and BST2 was identified as an independent unfavorable prognosis factor. Finally, we demonstrated that BST2 can promote proliferation capacity of tumor cells. In conclusion, HCC patients with higher BST2 expression were more predisposed to poorer clinical symptoms and unfavorable prognosis.

骨髓基质抗原2（BST2）是跨膜糖蛋白，在先天免疫中起重要作用。在这里，我们首先发现肝细胞癌（HCC）组织中BST2表达显着升高。高BST2与更大的肿瘤大小和更多的肿瘤数目密切相关。此外，BST2高表达的HCC患者的总生存期较差，BST2被认为是独立的不良预后因素。最后，我们证明了BST2可以促进肿瘤细胞的增殖能力。总之，BST2表达较高的HCC患者更容易出现较差的临床症状和不良预后。