A metal-organic framework based on Co(II), [Co₃(Ina)₂(HIna)₂(μ₂-OH₂)(L)](DMF)₄}_n (1, H₄L = 5,5′-(pyrazine-2,5-diyl)diisophthalic acid, HIna = isonicotinic acid), which has uncoordinated carboxylate groups and open N-donor sites, has been prepared by using the mixed-ligand approach under solvothermal conditions. Because of the synergetic role of dual functional sites of N-donor and free carboxylate groups, the resulting activated 1a demonstrates CO₂ uptake capacity at room temperature and outstanding catalytic property in cycloaddition of epoxides and CO₂ at mild conditions. Furthermore, the biological functional of the compound on the chronic obstructive pulmonary disease (COPD) treatment was evaluated. First, the relative expression of the tlr3 receptor on the lung mucosal epithelial cells was measured by RT-PCR. Then the inflammatory cytokines released by the lung mucosal epithelial cells were detected by ELISA detection kit after treatment.

基于钴（II）的金属-有机骨架，[CO ₃（伊那）₂（雏）₂（μ ₂ -OH ₂）（L）]（DMF）₄ } _Ñ（1，H ₄ L = 5,5通过在溶剂热条件下使用混合配体方法制备了具有不配位的羧酸酯基团和开放的N-供体位点的'-（吡嗪-2,5-二基）二间苯二甲酸，HIna =异烟酸。由于N-供体和游离羧酸根基团双重功能位点的协同作用，所得到的活化1a在室温下表现出CO ₂吸收能力，并且在环氧化物和CO ₂的环加成反应中具有出色的催化性能。在温和的条件下。此外，评估了该化合物对慢性阻塞性肺疾病（COPD）治疗的生物学功能。首先，通过RT-PCR测量tlr3受体在肺粘膜上皮细胞上的相对表达。处理后，用ELISA检测试剂盒检测肺粘膜上皮细胞释放的炎性细胞因子。