Do different IgG repertoires play a role in B‐ and T‐cell functional modulation during ontogeny? The “hooks without bait” theory,Immunology and Cell Biology

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Do different IgG repertoires play a role in B‐ and T‐cell functional modulation during ontogeny? The “hooks without bait” theory
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-04-28 , DOI: 10.1111/imcb.12335
Jefferson R Victor _{1,

2}

Affiliation

The mechanisms by which immunoglobulin (Ig)G can modulate immunity have been investigated over the past few decades. In the past three years, some studies have demonstrated that IgG can play a pivotal role in mediating complex interactions that result in functional lymphocyte modulation during maturation in self or offspring primary lymphoid organs. This effect appears to be dependent on the IgG repertoire in the absence of the influence of antigens and the functionality of diverse cell populations, including B, αβT (CD4 T and CD8 T), invariant natural killer T and γδT cells, in mice and humans. Based on the literature, especially on findings resulting from the therapeutic use of purified IgG (intravenous Ig) and recent pieces of evidence obtained by my group, the “hooks without bait” theory is described here to guide the future development of therapies for specific immune regulation.

中文翻译：

个体发育过程中，不同的IgG库是否在B细胞和T细胞功能调节中起作用？“无饵钩”理论

在过去的几十年中，已经研究了免疫球蛋白（Ig）G调节免疫的机制。在过去的三年中，一些研究表明，IgG可以在介导复杂的相互作用中发挥关键作用，这些相互作用导致自身或后代原发性淋巴器官成熟过程中功能性淋巴细胞的调节。在没有抗原影响的情况下，这种作用似乎依赖于IgG库；在小鼠和人类中，包括B，αβT（CD4 T和CD8 T），不变的自然杀伤性T细胞和γδT细胞在内的各种细胞群体的功能均不受抗原的影响。。根据文献，尤其是根据治疗性使用纯化的IgG（静脉注射Ig）的结果，以及我小组最近获得的证据，

更新日期：2020-04-28

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