Host CD8α+ and CD103+ dendritic cells prime transplant antigen‐specific CD8+ T cells via cross‐dressing,Immunology and Cell Biology

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Host CD8α+ and CD103+ dendritic cells prime transplant antigen‐specific CD8+ T cells via cross‐dressing
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-04-24 , DOI: 10.1111/imcb.12342
Bin Li _{1,

2,

3} , Chunni Lu ₂ , Sara Oveissi ₂ , Jing Song _{2,

4} , Kun Xiao ₂ , Damien Zanker _{2,

5} , Mubin Duan ₂ , Jianxin Chen ₆ , Huji Xu ₄ , Quanming Zou ₃ , Chao Wu ₃ , Jonathan W Yewdell ₇ , Weisan Chen ₂

Affiliation

The participation of dendritic cells (DCs) in CD8⁺ T‐cell‐mediated allograft rejection is a long‐standing question of great clinical relevance for tissue transplantation. Here, we show that Batf3^−/− mice demonstrate delayed allo‐skin graft rejection and are deficient in priming allo‐specific CD8⁺ T cells. Batf3^−/− mouse priming is restored by transferring either purified CD8α⁺ or CD103⁺ DCs, demonstrating the critical role of these cells in alloreactivity. Using D^b‐restricted antiviral F5 transgenic T‐cell receptor T cells, which we demonstrate are alloreactive with H‐2K^d, we show that cross‐dressing of CD8α⁺ and CD103⁺ primes CD8⁺ T‐cell or allo‐specific responses in vitro and in vivo . These findings suggest novel strategies for moderating tissue rejection based on interfering with DC cross‐dressing or subsequent interaction with T cells.

中文翻译：

宿主CD8α+和CD103 +树突状细胞通过异装引发抗原特异性CD8 + T细胞的移植

树突状细胞（DCs）参与CD8 ⁺ T细胞介导的同种异体移植排斥是一个长期存在的问题，与组织移植的临床意义重大。在这里，我们显示Batf3 ^-/-小鼠表现出延迟的同种异体皮肤排斥反应，并且在启动异种特异性CD8 ⁺ T细胞方面缺乏能力。通过转移纯化的CD8α ⁺或CD103 ⁺ DC可以恢复Batf3 ^-/-小鼠的启动作用，这证明了这些细胞在同种异体反应中的关键作用。我们证明了使用D ^b限制的抗病毒F5转基因T细胞受体T细胞与H-2K ^d具有同种反应性，我们证明CD8α ⁺和CD103 ⁺素数CD8 ⁺ T细胞或同种异体特异性应答在体外和体内。这些发现提出了基于干扰DC异装或随后与T细胞相互作用来减轻组织排斥的新策略。

更新日期：2020-04-24

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