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Host CD8α+ and CD103+ dendritic cells prime transplant antigen‐specific CD8+ T cells via cross‐dressing
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-04-24 , DOI: 10.1111/imcb.12342
Bin Li 1, 2, 3 , Chunni Lu 2 , Sara Oveissi 2 , Jing Song 2, 4 , Kun Xiao 2 , Damien Zanker 2, 5 , Mubin Duan 2 , Jianxin Chen 6 , Huji Xu 4 , Quanming Zou 3 , Chao Wu 3 , Jonathan W Yewdell 7 , Weisan Chen 2
Affiliation  

The participation of dendritic cells (DCs) in CD8+ T‐cell‐mediated allograft rejection is a long‐standing question of great clinical relevance for tissue transplantation. Here, we show that Batf3−/− mice demonstrate delayed allo‐skin graft rejection and are deficient in priming allo‐specific CD8+ T cells. Batf3−/− mouse priming is restored by transferring either purified CD8α+ or CD103+ DCs, demonstrating the critical role of these cells in alloreactivity. Using Db‐restricted antiviral F5 transgenic T‐cell receptor T cells, which we demonstrate are alloreactive with H‐2Kd, we show that cross‐dressing of CD8α+ and CD103+ primes CD8+ T‐cell or allo‐specific responses in vitro and in vivo . These findings suggest novel strategies for moderating tissue rejection based on interfering with DC cross‐dressing or subsequent interaction with T cells.

中文翻译:

宿主CD8α+和CD103 +树突状细胞通过异装引发抗原特异性CD8 + T细胞的移植

树突状细胞(DCs)参与CD8 + T细胞介导的同种异体移植排斥是一个长期存在的问题,与组织移植的临床意义重大。在这里,我们显示Batf3 -/-小鼠表现出延迟的同种异体皮肤排斥反应,并且在启动异种特异性CD8 + T细胞方面缺乏能力。通过转移纯化的CD8α +或CD103 + DC可以恢复Batf3 -/-小鼠的启动作用,这证明了这些细胞在同种异体反应中的关键作用。我们证明了使用D b限制的抗病毒F5转基因T细胞受体T细胞与H-2K d具有同种反应性,我们证明CD8α +和CD103 +素数CD8 + T细胞或同种异体特异性应答在体外体内。这些发现提出了基于干扰DC异装或随后与T细胞相互作用来减轻组织排斥的新策略。
更新日期:2020-04-24
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