Positive sense (+) RNA viruses exploit membranes from a variety of cellular organelles to support the amplification of their genomes. This association concurs with the formation of vesicles whose main morphological feature is that of being wrapped by a double membrane. In the case of the SARS‐CoV virus, the outer membrane is not discrete for each vesicle, but seems to be continuous and shared between many individual vesicles, a difference with other +RNA viruses whose nature has remained elusive. I present morphological, biochemical and pharmacological arguments defending the striking analogy of this arrangement and that of entangled, nascent Lipid Droplets whose birth has been aborted by an excess of Phosphatidic Acid. Since Phosphatidic Acid can be targeted with therapeutical purposes, considering this working hypothesis may prove important in tackling SARS‐CoV infection.

中文翻译：

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磷脂酸在 SARS-CoV 感染期间破坏 ER 膜的假设作用。

正向 (+) RNA 病毒利用各种细胞器的膜来支持其基因组的扩增。这种关联与囊泡的形成一致，其主要形态特征是被双层膜包裹。在 SARS-CoV 病毒的情况下，每个囊泡的外膜不是离散的，而是似乎是连续的，并且在许多单独的囊泡之间共享，这与其他性质仍然难以捉摸的 +RNA 病毒不同。我提出了形态学、生物化学和药理学的论据，为这种排列的惊人类比与纠缠的、新生的脂滴的相似性辩护，这些脂滴的诞生已被过量的磷脂酸中止。由于磷脂酸可以用于治疗目的，