Near‐Infrared Fluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury,Chinese Journal of Chemistry

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Near‐Infrared Fluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-05-19 , DOI: 10.1002/cjoc.202000166
Lingfeng Xu ₁ , Lihe Sun ₁ , Fang Zeng ₁ , Shuizhu Wu ₁

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In‐situ overexpressed hydrogen peroxide could serve as a biomarker for inflammation and ischemic kidney injury. Herein, a nanoprobe was developed for assay of hydrogen peroxide. The nanoprobe (TA‐TPABQ) was formed via the boronate ester groups between the hydrophilic tannic acid and the boric‐acid‐containing compound (TPABQ) as well as the hydrophobic interactions. The probe with good photostability shows good sensitivity and selectivity towards H₂O₂. The probe was adopted for identifying endogenous and exogenous H₂O₂ in living cells. Moreover, the probe was utilized for in vivo imaging experiments in acute abdomina and ankle inflammation mouse models as well as acute renal ischemia mouse model.

中文翻译：

近红外荧光纳米探针可检测炎症和缺血性肾损伤中的过氧化氢

原位过表达的过氧化氢可以作为炎症和缺血性肾损伤的生物标志物。在此，开发了用于检测过氧化氢的纳米探针。纳米探针（TA-TPABQ）是通过亲水性单宁酸和含硼酸的化合物（TPABQ）之间的硼酸酯基团以及疏水相互作用形成的。具有良好光稳定性的探针显示出对H ₂ O _2的良好灵敏度和选择性。该探针被用于鉴定活细胞中的内源性和外源性H ₂ O ₂。此外，该探针用于体内急性腹部和踝部炎症小鼠模型以及急性肾缺血小鼠模型的影像学实验。

更新日期：2020-05-19

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