Dosimetry in nuclear medicine often relies on estimating pharmacokinetics based on sparse temporal data. As analysis methods move toward image‐based three‐dimensional computation, it becomes important to interpolate and extrapolate these data without requiring manual intervention; that is, in a manner that is highly efficient and reproducible. Iterative least‐squares solvers are poorly suited to this task because of the computational overhead and potential to optimize to local minima without applying tight constraints at the outset.

中文翻译：

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技术说明：用于基于体素的目标放射性核素剂量测定的快速多指数曲线拟合算法。

核医学中的剂量测定法通常依赖于基于稀疏的时间数据来估计药代动力学。随着分析方法转向基于图像的三维计算，在不需要人工干预的情况下内插和外推这些数据变得非常重要。即以一种高效且可重现的方式。迭代最小二乘法求解器不适合该任务，因为其计算量大，并且有可能在不首先施加严格约束的情况下优化为局部最小值。