Conformational Selection as the Driving Force of Amyloid β Chiral Inactivation.,ChemBioChem

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Conformational Selection as the Driving Force of Amyloid β Chiral Inactivation.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-05-18 , DOI: 10.1002/cbic.202000237
Jevgenij A Raskatov ₁

Affiliation

Rippled upon reflection: Aβ‐CI has been proposed to operate by forming rippled cross‐β networks upon mixing of Aβ enantiomers, but the drastic kinetic effects are yet to be explained. DFT calculations showed that individual peptide strains adopt lower‐strain conformations in rippled than in pleated cross‐β sheets, thus suggesting that conformation selection is responsible for the observed kinetic effects.

中文翻译：

构象选择作为淀粉样β手性失活的驱动力。

反射后起波纹：有人提出，Aβ-CI可以通过在混合Aβ对映异构体时形成波纹状的交叉β网络来起作用，但是其剧烈的动力学效应尚待解释。DFT计算显示，与折叠的交叉β折叠片相比，波纹中的各个肽菌株在波纹中的构象更低，因此表明构象选择是观察到的动力学效应的原因。

更新日期：2020-05-18

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