During left ventricular opacification (LVO), myocardial contrast uptake (MCU) is frequently observed, but its clinical implication is uncertain. We aimed to investigate the diagnostic performance of MCU and its prognostic value in known or suspected coronary artery disease (CAD). Contrast echocardiography was retrospectively analyzed in 457 patients who had previous coronary angiography <12 mo before LVO. MCU was classified into replacement or interstitial patterns. Subendocardial patterns were further inspected. Events were defined as a primary composite of the occurrence of acute coronary syndrome, heart failure hospitalization, sustained ventricular tachycardia and all-cause mortality. MCU had an 87.6% sensitivity, 75.5% specificity, 73.0% positive predictive value and 87.7% negative predictive value in detecting CAD. After a median follow-up of 17.3 mo, 52 events occurred. Replacement, interstitial and subendocardial MCU patterns were associated with events. In conclusion, the presence of MCU was useful in identifying CAD and provided incremental prognostic value for clinical outcomes.

在左心室混浊 (LVO) 期间，经常观察到心肌造影剂摄取 (MCU)，但其临床意义尚不确定。我们旨在研究 MCU 的诊断性能及其在已知或疑似冠状动脉疾病 (CAD) 中的预后价值。对 457 名在 LVO 之前进行过冠状动脉造影 <12 个月的患者进行对比超声心动图回顾性分析。MCU 分为置换型或间隙型。进一步检查心内膜下模式。事件被定义为发生急性冠脉综合征、心力衰竭住院、持续性室性心动过速和全因死亡率的主要复合事件。MCU 在检测 CAD 方面具有 87.6% 的敏感性、75.5% 的特异性、73.0% 的阳性预测值和 87.7% 的阴性预测值。中位随访 17.3 个月后，发生了 52 起事件。置换、间质和心内膜下 MCU 模式与事件相关。总之，MCU 的存在有助于识别 CAD 并为临床结果提供增量预后价值。