Abstract Lung cancer is one of the major life-threatening cancers, with a higher mortality rate and morbidity. Curcumin acts as a potential anticancer agent but it shows less aqueous solubility so its clinical application is limited. In this present study, we developed curcumin-surface decorated Zinc Oxide nanoparticles ZnO@Cur to enhance its aqueous formulation and improve the anti-cancer activity of curcumin. The synthesized ZnO@Cur confirmed by various spectroscopies (UV–vis and fluorescence) and electroscopic techniques (Powder XRD, SEM, TEM, and DLS). ZnO@Cur dramatically suppressed the proliferation of A549 and HEL-299 cells and showed low toxicity in MTT assays. Compared with free ZnO and curcumin, ZnO@Cur significantly inhibited the migration ability of A549 cells. Moreover, the induction of apoptosis in A549 cells by ZnO@Cur was resulted by AO-EB staining. ZnO@Cur activated to promote intracellular ROS overproduction and induced apoptosis. ZnO@Cur shows excellent biocompatibility compared to free ZnO and Curcumin, the present study explained that ZnO@Cur as a safe and hopeful strategy for chemotherapeutics of lung cancer therapy and deserve for further clinical evaluations.

中文翻译：

---

简便合成的纳米姜黄素封装生物制造纳米颗粒诱导 ROS 介导的人肺癌细胞凋亡和迁移阻断

摘要 肺癌是危及生命的主要癌症之一，死亡率和发病率较高。姜黄素作为一种潜在的抗癌剂，但它的水溶性较差，因此其临床应用受到限制。在本研究中，我们开发了姜黄素表面修饰的氧化锌纳米颗粒 ZnO@Cur，以增强其水性配方并提高姜黄素的抗癌活性。合成的 ZnO@Cur 经各种光谱（UV-vis 和荧光）和电镜技术（粉末 XRD、SEM、TEM 和 DLS）证实。ZnO@Cur 显着抑制 A549 和 HEL-299 细胞的增殖，并在 MTT 测定中显示出低毒性。与游离的 ZnO 和姜黄素相比，ZnO@Cur 显着抑制 A549 细胞的迁移能力。而且，AO-EB 染色导致 ZnO@Cur 诱导 A549 细胞凋亡。ZnO@Cur 被激活以促进细胞内 ROS 过量产生并诱导细胞凋亡。与游离的 ZnO 和姜黄素相比，ZnO@Cur 显示出优异的生物相容性，本研究解释了 ZnO@Cur 作为肺癌治疗化学疗法的安全和有希望的策略，值得进一步的临床评估。