The association between intestinal permeability (IP) and body composition remains unclear. The gold standard differential sugar-absorption test is arduous to complete, with zonulin being increasingly used as an independent biomarker of IP. This pilot study aimed to explore the association between small IP, zonulin concentrations, and body composition in healthy adults. The urinary lactulose-rhamnose ratio was used to measure small IP. Serum zonulin, lipopolysaccharide (LPS) and high-sensitivity C-reactive protein (hs-CRP) were analyzed in serum. Body composition was measured using dual-energy X-ray absorptiometry and anthropometric measurements were collected. In total, 34 participants were included (12 males, median age 28 years, body mass index 24 kg/m2, waist circumference 77cm). No correlation was observed between the lactulose-rhamnose ratio and zonulin (r = -.016, P = .929). The lactulose-rhamnose ratio displayed a strong positive correlation with LPS (n 20, r = .536, P = .018) but did not correlate with body composition measures. Conversely, zonulin displayed a moderate positive correlation with waist circumference (r = .437, P = .042) in female participants and hs-CRP (r = .485, P = .004) in all participants. These findings raise important considerations for the measurement of small IP, warranting exploration in larger powered studies that address the limitations of the present study.

中文翻译：

---

通过酶联免疫吸附试验测量的血清 zonulin 可能不是健康成人小肠通透性的可靠标志物

肠道通透性 (IP) 与身体成分之间的关​​联仍不清楚。金标准差异糖吸收测试很难完成，而 zonulin 越来越多地用作 IP 的独立生物标志物。该试点研究旨在探讨健康成人的小 IP、zonulin 浓度和身体成分之间的关​​联。尿乳果糖-鼠李糖比率用于测量小IP。分析血清中的血清 zonulin、脂多糖 (LPS) 和高敏 C 反应蛋白 (hs-CRP)。使用双能 X 射线吸收测量法测量身体成分，并收集人体测量数据。总共包括 34 名参与者（12 名男性，中位年龄 28 岁，体重指数 24 kg/m2，腰围 77cm）。没有观察到乳果糖-鼠李糖比率和 zonulin 之间的相关性（r = -.016，P = .929）。乳果糖-鼠李糖比率与 LPS 呈强正相关（n = 20，r = .536，P = .018），但与身体成分测量无关。相反，zonulin 显示与女性参与者的腰围 (r = .437, P = .042) 和所有参与者的 hs-CRP (r = .485, P = .004) 呈中等正相关。这些发现提出了测量小 IP 的重要考虑因素，值得在更大的功率研究中进行探索，以解决本研究的局限性。zonulin 与女性参与者的腰围 (r = .437, P = .042) 和所有参与者的 hs-CRP (r = .485, P = .004) 均显示中度正相关。这些发现提出了测量小 IP 的重要考虑因素，值得在更大的功率研究中进行探索，以解决本研究的局限性。zonulin 与女性参与者的腰围 (r = .437, P = .042) 和所有参与者的 hs-CRP (r = .485, P = .004) 均显示中度正相关。这些发现提出了测量小 IP 的重要考虑因素，值得在更大的功率研究中进行探索，以解决本研究的局限性。