The study of corneal stromal keratocytes is motivated by its strong association with corneal health and visual function. They play a dominant role in the maintenance of corneal homeostasis and transparency through the production of collagens, proteoglycans and corneal crystallins. Trauma-induced apoptosis of keratocytes and replacement by fibroblasts and myofibroblasts disrupt the stromal matrix organization, resulting in corneal haze formation and vision loss. It is, therefore, important to understand the biology and behaviours of keratocytes and the associated stromal cell types (like fibroblasts, myofibroblasts, stromal stem cells) in wound healing, corneal pathologies (including keratoconus, keratitis, endothelial disorders) as well as different ophthalmic situations (such as collagen crosslinking/photodynamic treatment, keratoplasty and refractive surgery, and topical medications). The recent development of ex vivo propagation of keratocytes and stromal stem cells, and their translational applications, either via stromal injection or incorporated in bioscaffold, have been shown to restore the corneal transparency and regenerate native stromal tissue in animal models of corneal haze and other disorders.

中文翻译：

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角膜细胞生物学。

角膜基质角膜细胞与角膜健康和视觉功能的紧密关联推动了对角膜基质角膜细胞的研究。它们在胶原蛋白，蛋白聚糖和角膜结晶蛋白的生产中，在维持角膜稳态和透明性方面起着主导作用。创伤引起的角膜细胞凋亡以及成纤维细胞和成肌纤维细胞的置换破坏了基质基质的组织，导致角膜混浊形成和视力丧失。因此，重要的是要了解伤口愈合，角膜病变（包括圆锥角膜，角膜炎，内皮功能紊乱）以及不同眼科药物中角质形成细胞的生物学和行为以及相关的基质细胞类型（例如成纤维细胞，肌成纤维细胞，基质干细胞）情况（例如胶原蛋白交联/光动力治疗，角膜移植和屈光手术，以及局部用药）。在角膜混浊和其他疾病的动物模型中，角膜细胞和基质干细胞的离体繁殖的最新进展及其通过基质注射或掺入生物支架的翻译应用已显示可恢复角膜透明性并再生天然基质组织。 。