We studied the hepatic and renal impact of sodium metavanadate (SMV) exposure in African giant rats (AGR). Twelve male AGR were used and divided into two groups. The control group received sterile water while the SMV-exposed group received 3 mg/kg SMV intraperitoneally for 14 days. SMV exposed AGR groups showed significantly decreased activities of serum AST, ALT, ALP and creatinine concentration but increased blood urea nitrogen (BUN), albumin and globulin concentrations. Kidney ultrastructure examination revealed atrophy of the glomerular tuft, loss of podocytes, distortions of the endothelium and glomerular basement membrane. The liver sinusoids fenestration phenotypes were abnormal. Hepatocytes exhibited hypertrophy with uneven, crenated and dentate nuclei. SMV exposure induced activation of monocytes, as well as Kupffer and fibrous cells. Alterations in glomerular podocytes and cell-cell and cell matrix contact and inflammatory liver fibrosis are key events in progressive glomerular failure and hepatic damage due to SMV intoxication.

我们研究了非洲巨型大鼠（AGR）中偏钒酸钠（SMV）暴露对肝脏和肾脏的影响。使用十二个男性AGR，并分为两组。对照组接受无菌水，而暴露于SMV的组腹膜内接受3 mg / kg SMV，持续14天。暴露于SMV的AGR组显示血清AST，ALT，ALP和肌酐浓度明显降低，但血尿素氮（BUN），白蛋白和球蛋白浓度升高。肾脏超微结构检查显示肾小球簇的萎缩，足细胞的丢失，内皮和肾小球基底膜的变形。肝窦窦开窗表型异常。肝细胞肥大，核不均，齿状和齿状。SMV暴露诱导单核细胞以及库普弗和纤维细胞的活化。