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Activin and inhibin signaling: From regulation of physiology to involvement in the pathology of the female reproductive system
Cytokine ( IF 3.7 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.cyto.2020.155105 Enoch Appiah Adu-Gyamfi 1 , Francis Tanam Djankpa 2 , William Nelson 3 , Armin Czika 1 , Sanjay Kumar Sah 1 , Jones Lamptey 4 , Yu-Bin Ding 1 , Ying-Xiong Wang 1
Cytokine ( IF 3.7 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.cyto.2020.155105 Enoch Appiah Adu-Gyamfi 1 , Francis Tanam Djankpa 2 , William Nelson 3 , Armin Czika 1 , Sanjay Kumar Sah 1 , Jones Lamptey 4 , Yu-Bin Ding 1 , Ying-Xiong Wang 1
Affiliation
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Activins and inhibins - comprising activin A, B, AB, C and E, and inhibin A and B isoforms - belong to the transforming growth factor beta (TGFβ) superfamily. They regulate several biological processes, including cellular proliferation, differentiation and invasiveness, to enhance the formation and functioning of many human tissues and organs. In this review, we have discussed the role of activin and inhibin signaling in the physiological and female-specific pathological events that occur in the female reproductive system. The up-to-date evidence indicates that these cytokines regulate germ cell development, follicular development, ovulation, uterine receptivity, decidualization and placentation through the activation of several signaling pathways; and that their dysregulated expression is involved in the pathogenesis and pathophysiology of the numerous diseases, including pregnancy complications, that disturb reproduction. Hence, some of the isoforms have been suggested as potential biomarkers and therapeutic targets for the management of some of these diseases. Tackling the research directions highlighted in this review will enhance a detailed comprehension and the clinical utility of these cytokines.
中文翻译：
激活素和抑制素信号：从生理调节到参与女性生殖系统的病理
激活素和抑制素——包括激活素 A、B、AB、C 和 E，以及抑制素 A 和 B 同种型——属于转化生长因子 β (TGFβ) 超家族。它们调节多种生物过程，包括细胞增殖、分化和侵袭，以增强许多人体组织和器官的形成和功能。在这篇综述中，我们讨论了激活素和抑制素信号在女性生殖系统中发生的生理和女性特异性病理事件中的作用。最新证据表明，这些细胞因子通过激活多种信号通路来调节生殖细胞发育、卵泡发育、排卵、子宫容受性、蜕膜化和胎盘形成；并且它们的失调表达参与了许多疾病的发病机制和病理生理学，包括干扰生殖的妊娠并发症。因此，一些亚型已被建议作为治疗这些疾病的潜在生物标志物和治疗靶点。解决本综述中强调的研究方向将增强对这些细胞因子的详细理解和临床效用。
更新日期：2020-09-01
中文翻译：
激活素和抑制素信号：从生理调节到参与女性生殖系统的病理
激活素和抑制素——包括激活素 A、B、AB、C 和 E，以及抑制素 A 和 B 同种型——属于转化生长因子 β (TGFβ) 超家族。它们调节多种生物过程，包括细胞增殖、分化和侵袭，以增强许多人体组织和器官的形成和功能。在这篇综述中，我们讨论了激活素和抑制素信号在女性生殖系统中发生的生理和女性特异性病理事件中的作用。最新证据表明，这些细胞因子通过激活多种信号通路来调节生殖细胞发育、卵泡发育、排卵、子宫容受性、蜕膜化和胎盘形成；并且它们的失调表达参与了许多疾病的发病机制和病理生理学，包括干扰生殖的妊娠并发症。因此，一些亚型已被建议作为治疗这些疾病的潜在生物标志物和治疗靶点。解决本综述中强调的研究方向将增强对这些细胞因子的详细理解和临床效用。
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