OBJECTIVE To investigate the correlation between brain-derived neurotrophic factor (BDNF) and risk factors as well as functional outcome in post-stroke depression (PSD) or post-stroke anxiety (PSA). DESIGN A cohort study. SETTING Stroke patients admitted to an urban rehabilitation hospital. PARTICIPANTS This study included 162 stroke patients without any previous history of depression and anxiety. INTERVENTIONS Not applicable. MAIN OUTCOME MEASURES Sociodemographic information and comorbidities were recorded during hospital admission. Functional outcomes were assessed using functional independent measure (FIM) scores at time of admission and discharge. The influence of various factors such as BDNF and patient characteristics on functional outcome was investigated. Single-factor effect was examined using simple logistic regression, as was multi-factor effect using multiple logistic regression. The goodness-of-fit of those regression models was evaluated by the integrated area under ROC curve (iAUC). RESULTS PSD was diagnosed in 61 (37.7%) patients, and PSA was diagnosed in 40 (24.7%). Multiple logistic analysis showed that BDNF as well as divorce/separation and history of smoking were significantly associated with the occurrence of PSD but not with the occurrence of PSA. The model combining low BDNF level and divorce/separation improved the prediction for PSD. Among the variables analyzed for prediction of functional outcome, serum BDNF had a minimum correlation with motor FIM scores in PSD but no significant correlation with motor FIM scores in PSA. CONCLUSION BDNF is a valuable prediction for the occurrence of PSD but not for PSA. More strikingly, ischemic stroke patients who are divorced or separated with low serum BDNF have a much higher risk for PSD. BDNF has a minimum correlation with motor function outcome in PSD but no significant correlation with motor outcome in PSA.

中文翻译：

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血清BDNF与卒中后抑郁和卒中后焦虑的差异关联

目的探讨脑源性神经营养因子（BDNF）与卒中后抑郁（PSD）或卒中后焦虑（PSA）危险因素及功能结局的相关性。设计 一项队列研究。地点 入住城市康复医院的中风患者。参与者 本研究包括 162 名没有任何抑郁和焦虑病史的中风患者。干预 不适用。主要结局指标 住院期间记录社会人口学信息和合并症。在入院和出院时使用功能独立测量 (FIM) 评分评估功能结果。研究了各种因素如 BDNF 和患者特征对功能结果的影响。使用简单逻辑回归检验单因素效应，使用多元逻辑回归的多因素效应也是如此。这些回归模型的拟合优度通过 ROC 曲线下的积分面积 (iAUC) 进行评估。结果 61 名（37.7%）患者被诊断为 PSD，40 名（24.7%）患者被诊断为 PSA。多重逻辑分析显示BDNF、离婚/分居和吸烟史与PSD的发生显着相关，但与PSA的发生无关。结合低 BDNF 水平和离婚/分居的模型改进了对 PSD 的预测。在为预测功能结果而分析的变量中，血清 BDNF 与 PSD 中的运动 FIM 评分的相关性最小，但与 PSA 中的运动 FIM 评分没有显着相关性。结论 BDNF 是 PSD 发生的有价值的预测，但不是 PSA。更引人注目的是，离异或分居且血清 BDNF 水平低的缺血性卒中患者患 PSD 的风险要高得多。BDNF 与 PSD 运动功能结果的相关性最小，但与 PSA 运动结果无显着相关性。