Peroxygen-based chemotherapeutants are commonly used in treating ectoparasitic infections in fish. A majority of relevant studies address the effects of these substances on the targeted causative agents, but little is known about their physiological impacts on the host organism. This study documented the changes in the skin of Atlantic salmon (Salmo salar) exposed to peracetic acid (PAA), a peroxygen disinfectant with potent oxidative properties. Fish were exposed to three therapeutic concentrations of PAA-based disinfectant: 0, 0.6, and 2.4 ppm. The initial exposure time was 5 min, and two weeks after, fish were re-exposed to the same doses for 30 min. Skin colour was not dramatically affected by the PAA treatments. No gross pathologies, lesions, or wounds were observed in the skin of sampled fish. Histological evaluation revealed that fish treated with PAA appeared to have rough epidermal surface compared with the 0 ppm group, especially after the re-exposure. Morphometrics of mucous cells did not markedly vary amongst the treatments, although the group treated with 2.4 ppm displayed a relatively larger mucous cells 2 weeks after the first exposure. Transcriptional analysis was conducted for key markers that were previously identified to be involved in the mucosal response to PAA, and the results revealed that proteolysis-related genes were modulated more remarkably during the first exposure than during re-exposure. These data revealed that therapeutic doses of PAA induced morphomolecular changes in the skin of salmon, although the magnitude of alteration was marginal.

基于过氧的化学治疗剂通常用于治疗鱼类的寄生寄生虫感染。大多数相关研究都针对这些物质对目标病原体的影响，但对它们对宿主生物的生理影响知之甚少。这项研究记录了大西洋鲑鱼（Salmo salar）皮肤的变化）暴露于过氧乙酸（PAA），过氧消毒剂具有强氧化性。鱼暴露于三种治疗浓度的基于PAA的消毒剂：0、0.6和2.4 ppm。最初的暴露时间为5分钟，两周后，将鱼重新暴露于相同剂量的30分钟。PAA处理不会显着影响皮肤颜色。在采样鱼的皮肤中未观察到明显的病理，损伤或伤口。组织学评估表明，与0 ppm组相比，用PAA处理的鱼似乎具有粗糙的表皮表面，尤其是在再次暴露后。尽管在第一次接触后2周，用2.4 ppm处理的组显示出相对较大的粘液细胞，但在处理之间粘液细胞的形态没有明显变化。转录分析进行了关键标志物的分析，这些标志物先前被确定与粘膜对PAA的反应有关，结果表明，与首次暴露相比，蛋白水解相关的基因受到的调节更为显着。这些数据表明，治疗剂量的PAA可以诱导鲑鱼皮肤中的形态分子变化，尽管变化幅度很小。