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The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-18 , DOI: 10.1039/d0bm00586j Morgane Daurat 1 , Christophe Nguyen , Sofia Dominguez Gil , Vincent Sol , Vincent Chaleix , Clarence Charnay , Laurence Raehm , Khaled El Cheikh , Alain Morère , Michele Bernasconi , Andrea Timpanaro , Marcel Garcia , Frédérique Cunin , Jochen Roessler , Jean-Olivier Durand , Magali Gary-Bobo
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-18 , DOI: 10.1039/d0bm00586j Morgane Daurat 1 , Christophe Nguyen , Sofia Dominguez Gil , Vincent Sol , Vincent Chaleix , Clarence Charnay , Laurence Raehm , Khaled El Cheikh , Alain Morère , Michele Bernasconi , Andrea Timpanaro , Marcel Garcia , Frédérique Cunin , Jochen Roessler , Jean-Olivier Durand , Magali Gary-Bobo
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Porphyrin-based periodic mesoporous organosilica nanoparticles (PMO) synthesized from a large functional octatriethoxysilylated porphyrin precursor and allowing two-photon excitation photodynamic therapy (TPE-PDT) and NIR imaging were synthesized. These PMO were grafted with polyethylene glycol (PEG) moieties and an analogue of mannose 6-phosphate functionalized at the anomeric position (AMFA). AMFAs are known to efficiently target mannose 6-phosphate receptors (M6PRs) which are over-expressed in various cancers. Here, we demonstrated for the first time that M6PRs were over-expressed in rhabdomyosarcoma (RMS) cells and could be efficiently targeted with PMO–AMFA allowing TPE imaging and TPE-PDT of RMS cells. The comparison with healthy myoblasts demonstrated an absence of biological effects, suggesting a cancer cell specificity in the biomedical action observed.
中文翻译：
用基于卟啉的周期性介孔有机二氧化硅纳米颗粒靶向的甘露糖6-磷酸受体用于横纹肌肉瘤治疗。
合成了基于卟啉的周期性介孔有机二氧化硅纳米粒子（PMO），该纳米粒子是由功能性较大的八三乙氧基甲硅烷基化的卟啉前体合成的，并且可以进行双光子激发光动力疗法（TPE-PDT）和NIR成像。这些PMO接枝了聚乙二醇（PEG）部分和在异头位置官能化的6-磷酸甘露糖类似物（AMFA）。已知AMFA可有效靶向在多种癌症中过表达的甘露糖6磷酸受体（M6PR）。在这里，我们首次证明了M6PRs在横纹肌肉瘤（RMS）细胞中过表达，并且可以有效地靶向PMO-AMFA，从而可以对RMS细胞进行TPE成像和TPE-PDT。与健康的成肌细胞的比较表明没有生物学效应，
更新日期：2020-06-30
中文翻译：
用基于卟啉的周期性介孔有机二氧化硅纳米颗粒靶向的甘露糖6-磷酸受体用于横纹肌肉瘤治疗。
合成了基于卟啉的周期性介孔有机二氧化硅纳米粒子（PMO），该纳米粒子是由功能性较大的八三乙氧基甲硅烷基化的卟啉前体合成的，并且可以进行双光子激发光动力疗法（TPE-PDT）和NIR成像。这些PMO接枝了聚乙二醇（PEG）部分和在异头位置官能化的6-磷酸甘露糖类似物（AMFA）。已知AMFA可有效靶向在多种癌症中过表达的甘露糖6磷酸受体（M6PR）。在这里，我们首次证明了M6PRs在横纹肌肉瘤（RMS）细胞中过表达，并且可以有效地靶向PMO-AMFA，从而可以对RMS细胞进行TPE成像和TPE-PDT。与健康的成肌细胞的比较表明没有生物学效应，
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