In Reply Granzotto and Sensi hypothesize that the potential beneficial effects of minocycline in Alzheimer disease in our trial¹ may have been obscured by the inhibition of matrix metalloproteinase-9 activation of brain-derived neurotrophic factor (BDNF). Unfortunately, we did not save blood samples from participants that might have allowed us to test whether BDNF levels were reduced in those receiving minocycline. Of course, even if we had evidence that activated BDNF levels were reduced by minocycline in the trial, this would not necessarily explain the lack of minocycline’s efficacy in modifying Alzheimer progression.

中文翻译：

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Minocycline-来自失败回复的教训。

Granzotto和Sensi在答复中假设，米诺环素在我们的试验¹中对阿尔茨海默病的潜在有益作用可能已被抑制脑源性神经营养因子（BDNF）的基质金属蛋白酶9激活所掩盖。不幸的是，我们没有保存参与者的血液样本，这可能使我们测试了接受米诺环素治疗的患者的BDNF水平是否降低。当然，即使我们有证据表明在试验中米诺环素降低了激活的BDNF水平，也未必能说明缺乏米诺环素改善阿尔茨海默病进展的功效。