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Polysaccharide-Based Nanoparticles for Two-Step Responsive Release of Antitumor Drug.
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2020-05-18 , DOI: 10.1021/acsmedchemlett.0c00040 Hong-Guang Fu 1 , Yong Chen 1 , Qilin Yu 1 , Yu Liu 1
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2020-05-18 , DOI: 10.1021/acsmedchemlett.0c00040 Hong-Guang Fu 1 , Yong Chen 1 , Qilin Yu 1 , Yu Liu 1
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A novel two-step in situ method for targeted antitumor drug release by supramolecular assembly (Fc-CPT@HACD) was constructed using camptothecin prodrug (Fc-CPT) and β-cyclodextrin (β-CD)-modified hyaluronic acid (HACD). Benefiting from the overexpressed H2O2 and glutathione (GSH) in tumor cells, Fc-CPT@HACD can be disassembled by oxidation of ferrocene (Fc) to Fc+, leading to an efficient release of the anticancer drug camptothecin (CPT) to induce tumor cell apoptosis without affecting normal cells. The in vivo experiment results also demonstrated that Fc-CPT@HACD possessed higher anticancer efficiency than free CPT, accompanied by negligible side effects.
中文翻译：
基于多糖的纳米颗粒用于抗肿瘤药的两步响应释放。
利用喜树碱前药（Fc-CPT）和β-环糊精（β-CD）修饰的透明质酸（HACD）构建了一种超分子组装靶向性抗肿瘤药物的新的两步法（Fc-CPT @ HACD）。得益于肿瘤细胞中过表达的H 2 O 2和谷胱甘肽（GSH），Fc-CPT @ HACD可以通过将二茂铁（Fc）氧化为Fc +进行分解，从而将抗癌药物喜树碱（CPT）有效释放至诱导肿瘤细胞凋亡而不影响正常细胞。体内实验结果还表明，Fc-CPT @ HACD比游离CPT具有更高的抗癌效率，且副作用可忽略不计。
更新日期：2020-05-18
中文翻译：
基于多糖的纳米颗粒用于抗肿瘤药的两步响应释放。
利用喜树碱前药（Fc-CPT）和β-环糊精（β-CD）修饰的透明质酸（HACD）构建了一种超分子组装靶向性抗肿瘤药物的新的两步法（Fc-CPT @ HACD）。得益于肿瘤细胞中过表达的H 2 O 2和谷胱甘肽（GSH），Fc-CPT @ HACD可以通过将二茂铁（Fc）氧化为Fc +进行分解，从而将抗癌药物喜树碱（CPT）有效释放至诱导肿瘤细胞凋亡而不影响正常细胞。体内实验结果还表明，Fc-CPT @ HACD比游离CPT具有更高的抗癌效率，且副作用可忽略不计。
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