Treating COVID-19 with Chloroquine.,Journal of Molecular Cell Biology

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Treating COVID-19 with Chloroquine.
Journal of Molecular Cell Biology ( IF 5.3 ) Pub Date : 2020-05-18 , DOI: 10.1093/jmcb/mjaa014
Mingxing Huang _{1,

2} , Tiantian Tang _{3,

4} , Pengfei Pang _{2,

5} , Man Li _{2,

6} , Ruolan Ma _{7,

8} , Jiahui Lu ₁ , Jingxian Shu ₉ , Yingying You ₁₀ , Binghui Chen ₁₁ , Jiabi Liang ₉ , Zhongsi Hong ₁ , Huili Chen ₁ , Ling Kong ₁₂ , Dajiang Qin _{7,

12} , Duanqing Pei _{7,

12} , Jinyu Xia ₁ , Shanping Jiang _{3,

4} , Hong Shan _{2,

5}

Affiliation

Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University (SYSU), Zhuhai 519000, China.
Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China.
Department of Respiratory and Critical Care Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Institute of Pulmonary Diseases, Sun Yat-sen University, Guangzhou 510120, China.
Interventional Medical Center, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China.
Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, China.
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Department of Pharmacy, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China.
Department of Stomatology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China.
Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China.
Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510700, China.

A novel coronavirus disease 2019 (COVID-19) emerged around December 2019 in Wuhan, China and has spread rapidly worldwide (Lu et al., 2020). Until March 27, 2020, the Chinese health authorities had reported 82082 confirmed COVID-19 cases in China with 3298 deaths and 381443 confirmed cases with 20787 deaths outside China. The World Health Organization (WHO) named the virus SARS-CoV-2, which belongs to a distinct clade from the human severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV) (Zhu et al., 2020). At present, there is no effective therapy against this new virus. Identifying effective antiviral agents to treat the COVID-19 is of most urgency.

更新日期：2020-04-01

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