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New tools for transcriptome-wide mapping of m6A.
Nature Reviews Genetics ( IF 42.7 ) Pub Date : 2020-05-18 , DOI: 10.1038/s41576-020-0248-6
Dorothy Clyde 1
Affiliation  

Two papers in Nature Chemical Biology describe new methods for transcriptome-mapping of N6-methyladenosine (m6A), a covalent modification of RNA. In m6A-SEAL, modified adenosines can be tagged with different functional groups for different applications, whereas m6A-label-seq uses metabolic labelling to achieve single-nucleotide resolution.

中文翻译:

用于 m6A 转录组范围映射的新工具。

Nature Chemical Biology 上的两篇论文描述了对 N6-甲基腺苷 (m6A)(一种 RNA 的共价修饰)进行转录组作图的新方法。在 m6A-SEAL 中,修饰的腺苷可以针对不同的应用使用不同的官能团进行标记,而 m6A-label-seq 使用代谢标记来实现单核苷酸分辨率。
更新日期:2020-05-18
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