Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and between RNA splicing and increased oligodendrocyte development and myelination. Consistently, single-cell RNA sequencing showed cerebral atherosclerosis associated with higher oligodendrocyte abundance. A subset of proteins and modules associated with cerebral atherosclerosis was also associated with Alzheimer's disease, suggesting shared mechanisms.

中文翻译：

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脑动脉粥样硬化和阿尔茨海默病对人脑的共同蛋白质组学影响。

脑动脉粥样硬化通过不明确的过程导致痴呆。我们对 438 名老年人的背外侧前额叶皮层进行了蛋白质组测序，发现脑动脉粥样硬化与突触信号减少之间以及 RNA 剪接与少突胶质细胞发育和髓鞘形成增加之间存在关联。一致地，单细胞 RNA 测序显示脑动脉粥样硬化与较高的少突胶质细胞丰度相关。与脑动脉粥样硬化相关的蛋白质和模块的一个子集也与阿尔茨海默氏病有关，这表明存在共同的机制。