The point-of-care detection of pathogens in biological samples in resource-limited settings should be inexpensive, rapid, portable, simple and accurate. Here, we describe a custom-made fidget spinner that rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification. In Tiruchirappalli, India, the device enabled the on-site detection of infection with the naked eye within 50 min in urine samples from 39 patients suspected of having a urinary tract infection. We also show that, in 30 clinical samples of urinary tract infection, the device can be used to perform an antimicrobial susceptibility test for the antimicrobial drugs ciprofloxacin and cefazolin within 120 min. The fidget spinner could be used in low-resource settings as an inexpensive handheld point-of-care device for the rapid concentration and detection of pathogens in urine samples.

中文翻译：

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用于尿路感染的即时诊断的指尖陀螺。

在资源有限的环境中对生物样本中的病原体进行即时检测应该是廉价、快速、便携、简单和准确的。在这里，我们描述了一种定制的指尖陀螺，它可以将 1 毫升未稀释尿液样本中的病原体快速浓缩 100 倍以上，用于设备上比色检测细菌负荷和病原体鉴定。在印度蒂鲁吉拉伯利，该设备能够在 50 分钟内现场检测来自 39 名疑似尿路感染患者的尿液样本中的肉眼感染。我们还表明，在 30 个尿路感染临床样本中，该设备可用于在 120 分钟内对抗菌药物环丙沙星和头孢唑啉进行抗菌药敏试验。