Chronic wounds affect over 6.5 million Americans and are notoriously difficult to treat. Suboptimal oxygenation of the wound bed is one of the most critical and treatable wound management factors, but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable platform. Thus, we developed a low-cost alternative for continuous O₂ delivery and sensing comprising of an inexpensive, paper-based, biocompatible, flexible platform for locally generating and measuring oxygen in a wound region. The platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology, inkjet printing. Here, we demonstrate the functionality of the oxygenation patch, capable of increasing oxygen concentration in a gel substrate by 13% (5 ppm) in 1 h. The platform is able to sense oxygen in a range of 5–26 ppm. In vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.

慢性伤口影响了超过 650 万美国人，并且众所周知难以治疗。伤口床的欠佳氧合是最关键和可治疗的伤口管理因素之一，但现有的氧合系统无法在方便的可穿戴平台上同时测量和输送氧气。因此，我们开发了一种低成本的连续 O ₂替代方案输送和传感包括一个廉价的、基于纸张的、生物相容的、灵活的平台，用于在伤口区域局部产生和测量氧气。该平台利用了柔性微系统制造的最新发展，包括将纸作为基材并使用可扩展的制造技术，即喷墨打印。在这里，我们展示了氧合贴片的功能，能够在 1 小时内将凝胶基质中的氧浓度增加 13% (5 ppm)。该平台能够感应 5-26 ppm 范围内的氧气。体内研究证明了贴片的生物相容性及其将伤口床中的氧气水平提高一倍或三倍至临床相关水平的能力。