ABSTRACT

Estrogen has a significant role in regulating cell proliferation, growth, migration, aging, and many disease states. Estrogen shows its effects through estrogen receptors alpha, beta, and G protein-coupled estrogen receptor 1 (GPER1). The aim of this study is to evaluate serum GPER1 levels and its relationship with fibrosis score in chronic hepatitis B patients. The cases were selected from two university hospitals and consisted of patients who had not previously been treated for hepatitis B, were over 18. Quantitative sandwich enzyme immunoassay technique was used for measuring the serum levels of GPER1. The data evaluated were analyzed by using the statistical tests. Out of the 65 cases; 26 (40%) had hepatitis B, 39 (60%) were controls. Patients underwent liver biopsy. GPER1 levels were significantly high in Hepatitis B group (p < 0.001). Out of the 26 hepatitis B patients; 21(80,8%) had low-stage fibrosis, 5(19,2%) had high-stage fibrosis. When the GPER1 level was ≥017600000 the sensitivity, specificity, positive predictive value, and negative predictive value for the hepatitis B patients were found to be 96%, 87,7%, 96%, and 92,8%, respectively. GPER levels have shown high expression in patients with chronic hepatitis B.

摘要

雌激素在调节细胞增殖，生长，迁移，衰老和许多疾病状态中起重要作用。雌激素通过雌激素受体α，β和G蛋白偶联的雌激素受体1（GPER1）显示其作用。这项研究的目的是评估慢性乙型肝炎患者的血清GPER1水平及其与纤维化评分的关系。该病例选自两家大学医院，由以前未接受过乙型肝炎治疗的患者组成，年龄超过18岁。采用定量夹心酶免疫分析技术测量血清GPER1的水平。使用统计检验分析评估的数据。65例中；乙型肝炎占26（40％），对照组为39（60％）。患者接受肝活检。乙型肝炎组的GPER1水平显着较高（p <0.001）。在26名乙型肝炎患者中；低度肝纤维化为21（80.8％），高度肝纤维化为5（19.2％）。当GPER1≥017600000时，对乙型肝炎患者的敏感性，特异性，阳性预测值和阴性预测值分别为96％，87.7％，96％和92.8％。在慢性乙型肝炎患者中，GPER水平显示出高表达。