Objective: Assess the efficacy and safety of carbetocin, versus oxytocin in the prevention of postpartum hemorrhage in hypertensive women.

Study design: A randomized clinical trial.

Setting: Obstetrics and Gynecology Department of Suez Canal University Hospital.

Patients: One hundred and sixty hypertensive pregnant women who underwent CS.

Interventions: Patients were randomized to receive either 10 IU oxytocin or 100 μg carbetocin. Primary outcomes included estimated blood loss, blood transfusion, hemoglobin (HB), and hematocrit changes pre- and post-delivery and the use of additional uterotonics.

Results: The postoperative HB was not different from preoperative HB in the carbetocin group (11.8 ± 1.2 vs. 11.2 ± 1.2 g/dL) while it decreased significantly in the oxytocin group (12.1 ± 3.8 vs. 10.4 ± 1.1 g/dL, p < 0.001). Blood loss was significantly more among the oxytocin group (679.5 ± 200.25 vs. 424.75 ± 182.59 ml) in the carbetocin group (p < 0.001). Nausea, vomiting, and sweating were reported more significantly in oxytocin group patients.

Conclusion: Carbetocin was more effective than oxytocin in reducing intraoperative and postoperative blood loss.

目的：评估甲氧卡比霉素与催产素在预防高血压妇女产后出血中的疗效和安全性。

研究设计：随机临床试验。

单位：苏伊士运河大学医院妇产科。

患者：接受CS的160名高血压孕妇。

干预措施：患者被随机分配接受10 IU催产素或100μg卡比妥星。主要结局包括分娩前后估计的失血量，输血量，血红蛋白（HB）和血细胞比容变化，以及使用其他子宫收缩剂。

结果：卡比妥星组的术后HB与术前HB无差异（11.8±1.2 vs. 11.2±1.2 g / dL），而催产素组则明显降低（12.1±3.8 vs 10.4±1.1 g / dL，p <0.001）。在催产素组中，催产素组的失血率更高（679.5±200.25 vs. 424.75±182.59 ml）（p <0.001）。催产素组患者的恶心，呕吐和出汗更为明显。

结论：在减少术中和术后失血方面，碳卡比霉素比催产素更有效。